Art

J-GLOBAL ID：202002250991483517   Reference number：20A1297283

Bitterness-Suppressing Effect of Umami Dipeptides and Their Constituent Amino Acids on Diphenhydramine: Evaluation by Gustatory Sensation and Taste Sensor Testing

うま味ジペプチドとそれらの構成アミノ酸がジフェンヒドラミンに及ぼす苦味抑制効果:味覚感覚による評価および味覚センサ試験

Author (13)： Okuno Takayoshi (School of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Morimoto Shiori (School of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Nishikawa Haruka (School of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Haraguchi Tamami (School of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Kojima Honami (School of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Tsujino Hirofumi (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Arisawa Mitsuhiro (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Yamashita Taku (School of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Nishikawa Junichi (School of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Yoshida Miyako (School of Pharmaceutical Sciences, Mukogawa Women’s University) ,  Habara Masaaki (Intelligent Sensor Technology Inc.) ,  Ikezaki Hidekazu (Intelligent Sensor Technology Inc.) ,  Uchida Takahiro (School of Pharmaceutical Sciences, Mukogawa Women’s University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 68  Issue： 3  Page： 234-243(J-STAGE)  Publication year： 2020 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *histamine H1-receptor blocker ,...
Semi thesaurus term： Molecular Docking Simulation ,...

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Author keywords (10)： umami-peptide ,  taste sensor ,  human bitterness-suppressing agent ,  surface plasmon resonance study ,  docking simulation ,  umami-peptide ,  taste sensor ,  human bitterness-suppressing agent ,  surface plasmon resonance study ,  docking simulation

JST classification (2)： Structure-activity relationship of drugs  (GV01050B) ,  Basic research of other drugs  (GW23010K)

Substance index (3)： L-Asp-L-Asp-OH ,  L-Glu-L-Glu-OH ,  Diphenhydramine hydrochloride

Reference (58)：

• 1) Koyanagi K., Kubota T., Kobayashi D., Kihara T., Yoshida T., Miisho T., Saito Y., Uchigoshi H., Takaki J., Seo T., Shimazoe T., Yakugaku Zasshi, 133, 1215-1221 (2013).
• 2) MERCK MANUAL, “Nonadherence in Children.”: ‹https://www.merckmanuals.com/professional/pediatrics/principles-of-drug-treatment-in-children/nonadherence-in-children›, cited 25 May 2019.
• 3) Blume J., Ruano A., Wang S., Jacson D., Tylleskar T., Strand L., BMC Pediatr., 18, 117 (2018).
• 4) Committee for Medicinal Products for Human Use (CHMP) Paediatric Committee (PDCO) European Medicines Agency. “Guideline on pharmaceutical development of medicines for paediatric use. EMA/CHMP/QWP/805880/2012Rev.2,2013.”: ‹http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2013/07/WC500147002.pdf›, cited 1 August, 2019.
• 5) Hiraiwa S., Obayashi M., Kougo T., Yamano H., Saeki T., Anjyo S., The Journal of Pediatric Practice, 67, 1342-1346 (2004).

Terms in the title (11)： うま味 ,  ジペプチド ,  アミノ酸 ,  ジフェンヒドラミン ,  苦味 ,  抑制効果 ,  味覚 ,  感覚 ,  評価 ,  味覚センサ ,  試験