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J-GLOBAL ID：202002253048495457   Reference number：20A2684945

Biphasic Increases of Cell Surface Calreticulin Following Treatment with Mitoxantrone

ミトキサントロン治療後の細胞表面カルレチクリンの二相性増加

Author (10)： Azuma Yutaro (Department of Molecular Biology, Faculty of Pharmaceutical Sciences, Toho University) ,  Azuma Yutaro (Department of Medical Biochemistry, Faculty of Pharmaceutical Sciences, Toho University) ,  Azuma Yutaro (Department of Clinical Chemistry, Faculty of Pharmaceutical Sciences, Toho University) ,  Suzuki Kenichi (Department of Clinical Chemistry, Faculty of Pharmaceutical Sciences, Toho University) ,  Higai Koji (Department of Medical Biochemistry, Faculty of Pharmaceutical Sciences, Toho University) ,  Higai Koji (Department of Clinical Chemistry, Faculty of Pharmaceutical Sciences, Toho University) ,  Higai Koji (Laboratory of Medical Biochemistry, Faculty of Pharmaceutical Sciences, Toho University) ,  Matsumoto Kojiro (Department of Clinical Chemistry, Faculty of Pharmaceutical Sciences, Toho University) ,  Tada Shusuke (Department of Molecular Biology, Faculty of Pharmaceutical Sciences, Toho University) ,  Tada Shusuke (Department of Medical Biochemistry, Faculty of Pharmaceutical Sciences, Toho University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 10  Page： 1595-1599(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *tumor cell ,...
Semi thesaurus term： ER stress

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Author keywords (10)： apoptosis ,  calreticulin ,  caspase ,  endoplasmic reticulum (ER) stress ,  reactive oxygen species ,  apoptosis ,  calreticulin ,  caspase ,  endoplasmic reticulum (ER) stress ,  reactive oxygen species

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Mitoxantrone

Reference (26)：

• 1) Ellgaard L, Frickel EM. Calnexin, calreticulin, and ERp57: teammates in glycoprotein folding. Cell Biochem. Biophys., 39, 223-247 (2003).
• 2) Michalak M, Groenendyk J, Szabo E, Gold LI, Opas M. Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. Biochem. J., 417, 651-666 (2009).
• 3) Williams DB. Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum. J. Cell Sci., 119, 615-623 (2006).
• 4) Garg AD, Nowis D, Golab J, Vandenabeele P, Krysko DV, Agostinis P. Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation. Biochim. Biophys. Acta, 1805, 53-71 (2010).
• 5) Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, Bratton DL, Oldenborg PA, Michalak M, Henson PM. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell, 123, 321-334 (2005).

Terms in the title (5)： ミトキサントロン ,  治療 ,  細胞表面 ,  カルレチクリン ,  二相性