Art

J-GLOBAL ID：202002253122045097   Reference number：20A1248272

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

単一ドメインのラクダ抗体によるベータtacウイルスの強力な中和のための構造基盤【JST・京大機械翻訳】

Author (26)： Wrapp Daniel (Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA) ,  De Vlieger Dorien (VIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium) ,  De Vlieger Dorien (Department of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium) ,  De Vlieger Dorien (Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium) ,  Corbett Kizzmekia S. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Torres Gretel M. (Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA) ,  Wang Nianshuang (Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA) ,  Van Breedam Wander (VIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium) ,  Van Breedam Wander (Department of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium) ,  Roose Kenny (VIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium) ,  Roose Kenny (Department of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium) ,  van Schie Loes (VIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium) ,  van Schie Loes (Department of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium) ,  Hoffmann Markus (Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Gottingen, Germany) ,  Pohlmann Stefan (Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, 37077 Gottingen, Germany) ,  Pohlmann Stefan (Faculty of Biology and Psychology, University Gottingen, 37077 Gottingen, Germany) ,  Graham Barney S. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Callewaert Nico (VIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium) ,  Callewaert Nico (Department of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium) ,  Schepens Bert (VIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium) ,  Schepens Bert (Department of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium) ,  Schepens Bert (Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium) ,  Saelens Xavier (VIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium) ,  Saelens Xavier (Department of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium) ,  Saelens Xavier (Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium) ,  McLellan Jason S. (Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 181  Issue： 5  Page： 1004-1015.e15  Publication year： 2020 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Coronaviruses make use of a la...

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Thesaurus term： crystal structure ,  *antibody ,  receptor ,  pathogenicity ,  *Camelus ,  Membrane Fusion ,  epitope ,  Coronavirus ,  cross reactivity ,  receptor binding ,  envelope protein ,  host cell ,  Single Domain Antibodies ,  Severe acute respiratory syndrome-related coronavirus
Semi thesaurus term： SARSウイルス ,  重症急性呼吸器症候群 , 【Automatic Indexing@JST】

Author keywords (5)： COVID-19 ,  SARS ,  MERS ,  SARS-CoV-2 ,  nanobody

JST classification (1)： Physiology and pathogenicity of virus infection  (EG04042Y)

Terms in the title (7)： 単一ドメイン ,  ラクダ ,  抗体 ,  TAC ,  ウイルス ,  中和 ,  基盤