Art

J-GLOBAL ID：202002253484149354   Reference number：20A0481335

Cathepsin K inhibition-induced mitochondrial ROS enhances sensitivity of cancer cells to anti-cancer drugs through USP27x-mediated Bim protein stabilization

カテプシンK阻害誘導ミトコンドリアROSは,USP27X媒介Bim蛋白質安定化を介して抗癌剤に対する癌細胞の感受性を増強する【JST・京大機械翻訳】

Author (10)： Seo Seung Un (Department of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-Gu, Daegu, 42601, South Korea) ,  Woo Seon Min (Department of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-Gu, Daegu, 42601, South Korea) ,  Kim Min Wook (Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, South Korea) ,  Lee Hyun-Shik (KNU-Center for Nonlinear Dynamics, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu, 41566, South Korea) ,  Kim Sang Hyun (Deaprtment of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41566, South Korea) ,  Kang Sun Chul (Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, 38453, South Korea) ,  Lee Eun-Woo (Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, South Korea) ,  Min Kyoung-jin (Department of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-Gu, Daegu, 42601, South Korea) ,  Min Kyoung-jin (New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), 80 Cheombokro, Dong-gu, Daegu, 41061, South Korea) ,  Kwon Taeg Kyu (Department of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-Gu, Daegu, 42601, South Korea)
Material： Redox Biology
Volume： 30  Page： Null  Publication year： 2020 
JST Material Number： W3135A  ISSN： 2213-2317  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Cathepsin K (Cat K) is express...

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Thesaurus term： apoptosis ,  down-regulation ,  Mammalia ,  human(primates) ,  up-regulation ,  *tumor cell ,  proteasome ,  TNF ,  *protein ,  heterotrans plantation ,  sensitization(immunology) ,  *mitochondria ,  *cathepsin ,  *antitumor drug ,  cell death

Author keywords (6)： Apoptosis ,  Bim ,  Cathepsin K ,  USP27x ,  Mitochondria ,  Raptor

JST classification (1)： Cell physiology in general  (EF02010S)

Terms in the title (11)： カテプシンK ,  阻害 ,  誘導 ,  ミトコンドリア ,  ROS ,  Bim蛋白質 ,  安定化 ,  抗癌剤 ,  癌細胞 ,  感受性 ,  増強