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J-GLOBAL ID：202002254196665037   Reference number：20A1075916

A missense mutation of Leu74Pro of OGR1 found in familial amelogenesis imperfecta actually causes the loss of the pH-sensing mechanism

家族性エナメル質形成不全症において発見されたOGR1のLeu74Proのミスセンス変異はpH感知機構の消失を実際的に引き起こす【JST・京大機械翻訳】

Author (4)： Sato Koichi (Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371-8512, Japan) ,  Mogi Chihiro (Laboratory of Integrated Signaling System, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371-8512, Japan) ,  Mighell Alan J. (Department of Oral Biology, School of Dentistry, St James’s University Hospital, University of Leeds, Leeds, LS9 7TF, UK) ,  Okajima Fumikazu (Laboratory of Signal Transduction, Faculty of Pharmaceutical Sciences, Aomori University, Aomori, 030-0943, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 526  Issue： 4  Page： 920-926  Publication year： 2020 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Ovarian cancer G protein-coupl...

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Thesaurus term： proton ,  conformational transition ,  Cell Membrane ,  receptor ,  Proteins ,  metal ion ,  Transfection ,  wild type ,  ovarian tumor ,  *missense mutation ,  internalization ,  HEK293 cell ,  histidine residue ,  Endomembrane system ,  aliphatic amine ,  aliphatic carboxylic acid ,  branched-chain amino acid ,  amino acid ,  nitrogen heterocyclic compound

Author keywords (5)： Extracellular acidification ,  G protein-coupled receptor ,  Intracellular Ca²⁺ ,  Missense variant ,  OGR1

JST classification (1)： Receptors on cell membrane  (EF04030C)

Substance index (2)： Leucine ,  Proline

Terms in the title (7)： 家族 ,  エナメル質形成不全症 ,  発見 ,  OGR1 ,  ミスセンス変異 ,  pH ,  感知