Art

J-GLOBAL ID：202002254505055823   Reference number：20A2436069

DESIGN AND SYNTHESIS OF 4′-CYANO DIDEOXY ISONUCLEOSIDES AND THEIR ACTIVITY AGAINST HIV-1 AND HBV

4′-シアノジデオキシイソヌクレオシドの設計と合成およびHIV-1ならびにHBVに対する活性

Author (13)： ONITSUKA Kengo (Sojo Univ., Kumamoto, JPN) ,  YAMAGUCHI Kakeru (Sojo Univ., Kumamoto, JPN) ,  YAMAGUCHI Kakeru (National Center for Global Health and Medicine Res. Inst., Tokyo, JPN) ,  TOKUDA Ryoh (Sojo Univ., Kumamoto, JPN) ,  HIGASHI-KUWATA Nobuyo (National Center for Global Health and Medicine Res. Inst., Tokyo, JPN) ,  KUWAHARA Shunsuke (Toho Univ., Chiba, JPN) ,  KUMAMOTO Hiroki (Nihon Pharmaceutical Univ., Saitama, JPN) ,  MAEDA Kenji (National Center for Global Health and Medicine Res. Inst., Tokyo, JPN) ,  HARAGUCHI Kazuhiro (Nihon Pharmaceutical Univ., Saitama, JPN) ,  MITSUYA Hiroaki (National Center for Global Health and Medicine Res. Inst., Tokyo, JPN) ,  MITSUYA Hiroaki (National Inst. of Health, MD, USA) ,  MITSUYA Hiroaki (Kumamoto Univ. School of Medicine, Kumamoto, JPN) ,  IMOTO Shuhei (Sojo Univ., Kumamoto, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 100  Issue： 10  Page： 1599-1612  Publication year： Oct. 01, 2020 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： HIV-1 Reverse Transcriptase ,...

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JST classification (2)： Nucleosides,nucleotides  (CF10060K) ,  Basic research of antiviral drugs  (GW17040O)

Substance index (5)： (2S,4R)-4-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolane-2-carbonitrile ,  methyl (2S)-2-({[(2S,4R)-4-(6-aminopurin-9-yl)-2-cyanooxolan-2-yl]methoxy(phenoxy)phosphoryl}amino)propanoate ,  Entecavir ,  Darunavir ,  安息香酸[(2S,4S)-2-[(tert-ブチルジフェニルシリルオキシ)メチル]-4-ヒドロキシテトラヒドロフラン-2-イル]メチル

Reference (25)：

• L. Menéndez-Arias, Antivir. Res., 2013, 98, 93.
• F. Morfin and D. Thouvenot, J. Clin. Virol., 2003, 26, 29.
• F. Zoulim and S. Locarnini, Gastroenterology, 2009, 137, 1593.
• P. Merino, 'Chemical Synthesis of Nucleoside Analogues', Wiley & Sons Inc., NewJersey, 2013.
• T. Cihlar and A. S. Ray, Antivir. Res., 2010, 85, 39.

Terms in the title (4)： 設計 ,  HIV-1 ,  HBV ,  活性