Art

J-GLOBAL ID：202002254821319931   Reference number：20A0501469

Study on the Multitarget Synergistic Effects of Kai-Xin-San against Alzheimer’s Disease Based on Systems Biology

システム生物学に基づくAlzheimer病に対するKai-Xin-Sanの多標的相乗効果に関する研究【JST・京大機械翻訳】

Author (8)： Guo Sirui (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016 Liaoning, China) ,  Guo Sirui (Department of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China) ,  Wang Jiahong (School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016 Liaoning, China) ,  Wang Yunjia (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016 Liaoning, China) ,  Zhang Ying (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016 Liaoning, China) ,  Bi Kaishun (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016 Liaoning, China) ,  Zhang Zhou (School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016 Liaoning, China) ,  Li Qing (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016 Liaoning, China)
Material： Oxidative Medicine and Cellular Longevity (Web)  (Oxidative Med Cell Longev (Web))
Volume： 2019  Page： Null  Publication year： 2019 
JST Material Number： U7012A  ISSN： 1942-0900  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Kai-Xin-San (KXS), a classical...

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Thesaurus term： plasma(blood) ,  rat ,  anti-inflammatory action ,  apoptosis ,  *potentiation ,  in vitro experiment ,  animal ,  *Alzheimer disease ,  herb ,  phosphorylation ,  acetylcholinesterase ,  Chinese drug ,  up-regulation ,  protein ,  inflammation

JST classification (3)： Cell physiology in general  (EF02010S) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Biological function  (EB03040U)

Reference (52)：

• Y. Hou, Y. Nie, B. Cheng, J. Tao, X. Ma, M. Jiang, J. Gao, G. Bai, "Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa-induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways," Acta Pharmaceutica Sinica B, vol. 6, no. 3, pp. 212-221, 2016.
• Y. Chen, C. Wang, S. Chen, S. Zhang, L. Yang, Y. Li, "Systems pharmacology dissection of multi-scale mechanisms of action of Huo-Xiang-Zheng-Qi formula for the treatment of gastrointestinal diseases," Frontiers in Pharmacology, vol. 9, 2018.
• Y. Yao, X. Zhang, Z. Wang, C. Zheng, P. Li, C. Huang, W. Tao, W. Xiao, Y. Wang, L. Huang, L. Yang, "Deciphering the combination principles of traditional Chinese medicine from a systems pharmacology perspective based on Ma-huang decoction," Journal of Ethnopharmacology, vol. 150, no. 2, pp. 619-638, 2013.
• X. Zhang, Z. Fu, L. Meng, M. He, Z. Zhang, "The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease," Frontiers in Aging Neuroscience, vol. 10, pp. 359, 2018.
• M. Jazvinscak Jembrek, P. R. Hof, G. Simic, "Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation," Oxidative Medicine and Cellular Longevity, vol. 2015, pp. 17, 2015.

Terms in the title (6)： システム生物学 ,  Alzheimer病 ,  SAN ,  標的 ,  相乗効果 ,  研究