Art

J-GLOBAL ID：202002254897125561   Reference number：20A0533349

Toll-like receptor 7 agonist imiquimod prevents the progression of SLE in MRL/lpr mice via inhibiting the differentiation of T follicular helper cells

Toll様受容体7作動薬イミキモドはT濾胞ヘルパー細胞の分化を阻害することによりMRL/lprマウスにおけるSLEの進行を予防する【JST・京大機械翻訳】

Author (11)： Duan Xiangguo (Department of Laboratory Medicine, College of Clinical Medicine, Ningxia Medical University, 750004 Yinchuan, PR China) ,  Duan Xiangguo (Department of Laboratory Surgery, General Hospital of Ningxia Medical University, 750004 Yinchuan, PR China) ,  Shen Chunxiu (School of Basic Medical Sciences , Ningxia Medical University, 750004 Yinchuan, PR China) ,  Zhang Xiaoyu (School of Basic Medical Sciences , Ningxia Medical University, 750004 Yinchuan, PR China) ,  Wu Lihua (Department of Laboratory Medicine, College of Clinical Medicine, Ningxia Medical University, 750004 Yinchuan, PR China) ,  Chen Jian (Guolong Hospital, 750004 Yinchuan, PR China) ,  Ma Bin (Department of Oncology Surgery, The First People’s Hospital of Yinchuan, 750001 Yinchuan, PR China) ,  Wang Qi (School of Basic Medical Sciences , Ningxia Medical University, 750004 Yinchuan, PR China) ,  Sun Peng (School of Basic Medical Sciences , Ningxia Medical University, 750004 Yinchuan, PR China) ,  Lan Yaru (School of Basic Medical Sciences , Ningxia Medical University, 750004 Yinchuan, PR China) ,  Su Chunxia (School of Basic Medical Sciences , Ningxia Medical University, 750004 Yinchuan, PR China)
Material： International Immunopharmacology  (Int Immunopharmacol)
Volume： 80  Page： Null  Publication year： 2020 
JST Material Number： T0026B  ISSN： 1567-5769  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Previous research has recently...

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Thesaurus term： Serum ,  immunological tolerance ,  *helper T cell ,  transcription factor ,  antinuclear antibody ,  autoimmune disease ,  systemic lupus erythematosus ,  antibody ,  *ovarian follicle ,  Death ,  natural immunity ,  mRNA expression ,  T follicular helper cells ,  CD4-Positive T-Lymphocytes ,  reaction ,  immune response ,  suppression and control

Author keywords (5)： Toll-like receptor 7 ,  T follicular helper (Tfh) cells ,  SLE ,  MRL/lpr mice ,  Immune tolerance

JST classification (1)： Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Substance index (1)： Imiquimod

Terms in the title (11)： Toll様受容体7 ,  作動薬 ,  イミキモド ,  濾胞 ,  ヘルパー細胞 ,  分化 ,  阻害 ,  LPR ,  マウス ,  SLE ,  予防