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J-GLOBAL ID:202002255037174661   Reference number:20A1408224

PK/PD/PG analysis of nitroglycerin in infants with congenital heart disease and pulmonary arterial hypertension

肺高血圧を伴う小児先天性心疾患患者におけるニトログリセリンのPK/PD/PG解析
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Material:
Issue: 41  Page: 116-124  Publication year: Jun. 20, 2020 
JST Material Number: Y0720A  ISSN: 0914-4366  Document type: Article
Article type: 原著論文  Country of issue: Japan (JPN)  Language: JAPANESE (JA)
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Clinical biopharmacy  ,  Drug therapy(=pharmacotherapy)for cardiovascular system diseases 
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Reference (12):
  • Galiè N, Seeger W, Naeije R, Simonneau G, Rubin LJ. Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43: 81S-88S.
  • Floh AA, Krawczeski CD, Schwartz SM. Perioperative care of the child with congenital heart disease. Wheeler DS, Wong HR, Shanley TP (Eds). Pediatric Critical Care Medicine, 2nd. ed. London: Springer-Verlag, 2014: 329-51.
  • Pearl RG, Rosenthal MH, Schroeder JS, Ashton JP. Acute hemodynamic effects of nitroglycerin in pulmonary hypertension. Ann Intern Med 1983; 99: 9-13.
  • Chen Z, Zhang J, Stamler JS. Identification of the enzymatic mechanism of nitroglycerin bioactivation. Proc Natl Acad Sci USA 2002; 99: 8306-11.
  • Lang BS, Gorren AC, Oberdorfer G, Wenzl MV, Furdui CM, Poole LB, et al. Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction in intermediates revealed by crystallography and mass spectrometry. J Biol Chem 2012; 287: 38124-34.
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