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J-GLOBAL ID：202002255242589441   Reference number：20A0192323

Design, synthesis and in vitro evaluation of fangchinoline derivatives as potential anticancer agents

有望な抗癌剤としてのファンギノリン誘導体の設計,合成およびin vitro評価【JST・京大機械翻訳】

Author (7)： Zhang Yan-chun (College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Prod...) ,  Gao Xiu-zheng (College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Prod...) ,  Liu Chao (Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences, 202 Gongye North Road, Jinan 25...) ,  Wang Mu-xuan (College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Prod...) ,  Zhang Rui-rui (Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences, 202 Gongye North Road, Jinan 25...) ,  Sun Jin-yue (Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences, 202 Gongye North Road, Jinan 25...) ,  Liu Yu-fa (College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Prod...)
Material： Bioorganic Chemistry  (Bioorg Chem)
Volume： 94  Page： Null  Publication year： 2020 
JST Material Number： E0823A  ISSN： 0045-2068  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The isolation and modification...

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Thesaurus term： cell proliferation ,  *in vitro experiment ,  *antitumor drug ,  A549 cell ,  quantitative polymerase chain reaction ,  apoptosis ,  cell cycle ,  Western blotting ,  side effect ,  tumor cell ,  cytotoxicity ,  flow cytometry ,  mitochondria ,  dyeing ,  *blower

Author keywords (4)： Fangchinoline derivatives ,  Anti-proliferative ,  Apoptosis-inducing ,  Molecular mechanisms

JST classification (1)： Enzyme in general  (EB09010D)

Terms in the title (4)： 抗癌剤 ,  誘導体 ,  設計 ,  評価