Art

J-GLOBAL ID：202002255434485001   Reference number：20A1044685

Infiltration of CD163-positive macrophages in glioma tissues after treatment with anti-PD-L1 antibody and role of PI3Kγ inhibitor as a combination therapy with anti-PD-L1 antibody in in vivo model using temozolomide-resistant murine glioma-initiating cells

抗PD-L1抗体による治療後の神経膠腫組織におけるCD163陽性マクロファージの浸潤とデモゾロミド耐性マウス神経膠腫幹細胞を用いたin vivoモデルにおける抗PD-L1抗体との併用療法としてのPI3Kγ阻害剤の役割

Author (10)： Miyazaki Tsubasa (Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Miyazaki Tsubasa (Cell-Medicine, Inc, Tsukuba Science City, Ibaraki, Japan) ,  Ishikawa Eiichi (Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Matsuda Masahide (Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Sugii Narushi (Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Kohzuki Hedihiro (Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Akutsu Hiroyoshi (Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Sakamoto Noriaki (Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Takano Shingo (Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan) ,  Matsumura Akira (Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan)
Material： Brain Tumor Pathology. Supplement  (日本脳腫瘍病理学会学術集会プログラム・抄録号)
Volume： 37  Issue： 2  Page： 41-49  Publication year： 2020 
JST Material Number： F2794A  Document type： Proceedings
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antibody ,...
Semi thesaurus term： PD-L1 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A1044685&from=J-GLOBAL&jstjournalNo=F2794A") }}

Author keywords (6)： Immunotherapy ,  Glioblastoma ,  PD-L1 ,  IPI-549 ,  M2 macrophage ,  Immune checkpoint inhibitor

JST classification (3)： Experimental treatment for tumors  (GE02040Y) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic neurology  (GN01020W)

Substance index (2)： IPI-549 ,  Temozolomide

Terms in the title (15)： 抗PD-L1抗体 ,  治療 ,  神経膠腫 ,  組織 ,  CD163 ,  マクロファージ ,  浸潤 ,  耐性 ,  マウス ,  幹細胞 ,  モデル ,  併用療法 ,  PI3Kγ ,  阻害剤 ,  役割