Art

J-GLOBAL ID：202002256025394785   Reference number：20A1877794

Nasal absorption enhancement of protein drugs independent to their chemical properties in the presence of hyaluronic acid modified with tetraglycine-L-octaarginine

テトラグリシン-L-オクタアルギニンで修飾したヒアルロン酸存在下でのそれらの化学的性質に依存しない蛋白質薬物の鼻吸収増強【JST・京大機械翻訳】

Author (13)： Tomono Takumi (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Yagi Haruya (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Ukawa Masami (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Ishizaki Seiya (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Miwa Takahiro (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Nonomura Mao (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Igi Ryoji (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Kumagai Hironori (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) ,  Kumagai Hironori (Life Science Materials Laboratory, ADEKA Co., 7-2-34, Higashiogu, Arakawa-ku, Tokyo 116-8553, Japan) ,  Miyata Kohei (Life Science Materials Laboratory, ADEKA Co., 7-2-34, Higashiogu, Arakawa-ku, Tokyo 116-8553, Japan) ,  Tobita Etsuo (Life Science Materials Laboratory, ADEKA Co., 7-2-34, Higashiogu, Arakawa-ku, Tokyo 116-8553, Japan) ,  Kobayashi Hideo (Pharmaceutical and Biomedical Analysis Department, DAIICHI SANKYO RD NOVARE Co., Ltd., 1-16-13, Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan) ,  Sakuma Shinji (Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan)
Material： European Journal of Pharmaceutics and Biopharmaceutics  (Eur J Pharm Biopharm)
Volume： 154  Page： 186-194  Publication year： 2020 
JST Material Number： B0129B  ISSN： 0939-6411  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Our previous mouse studies dem...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A1877794&from=J-GLOBAL&jstjournalNo=B0129B") }}

Thesaurus term： molecular weight ,  polysaccharide ,  biological preparation ,  *protein preparation ,  *hyaluronic acid ,  subcutaneous administration ,  spacer ,  nasal mucosa ,  isoelectric point ,  bioavailability ,  analogical material ,  absorption promoter
Semi thesaurus term： グルカゴン様ペプチド-1 ,  *オクタアルギニン ,  エキセンジン-4 , 【Automatic Indexing@JST】

Author keywords (6)： Biologics ,  Protein drugs ,  Absorption enhancer ,  Cell-penetrating peptide ,  Hyaluronic acid ,  tetraglycine-L-octaarginine-linked hyaluronic acid

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Terms in the title (8)： テトラグリシン ,  オクタアルギニン ,  修飾 ,  ヒアルロン酸 ,  化学的性質 ,  蛋白質薬物 ,  鼻吸収 ,  増強