Art

J-GLOBAL ID：202002256035539083   Reference number：20A1471554

Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes

アベマシクリブはリソソーム由来細胞質液胞の形成を特徴とする癌細胞における非定型細胞死を誘導する

Author (10)： Hino Hirotsugu (Department of Biochemistry, Tokyo Medical University, Tokyo, Japan) ,  Hino Hirotsugu (Division of Anatomical Science, Department of Functional Morphology, Nihon University School of Medicine, Tokyo, Japan) ,  Iriyama Noriyoshi (Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan) ,  Kokuba Hiroko (Joint Research Center for Basic Medical Science, Tokyo Medical University, Tokyo, Japan) ,  Kazama Hiromi (Department of Biochemistry, Tokyo Medical University, Tokyo, Japan) ,  Moriya Shota (Department of Biochemistry, Tokyo Medical University, Tokyo, Japan) ,  Takano Naoharu (Department of Biochemistry, Tokyo Medical University, Tokyo, Japan) ,  Hiramoto Masaki (Department of Biochemistry, Tokyo Medical University, Tokyo, Japan) ,  Aizawa Shin (Division of Anatomical Science, Department of Functional Morphology, Nihon University School of Medicine, Tokyo, Japan) ,  Miyazawa Keisuke (Department of Biochemistry, Tokyo Medical University, Tokyo, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 111  Issue： 6  Page： 2132-2145  Publication year： 2020 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： A549 cell ,...
Semi thesaurus term： CDK4/6 inhibitor ,...

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Author keywords (5)： abemaciclib ,  CDK4/6 inhibitor ,  lysosome ,  vacuole formation ,  V-ATPase

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (3)： Abemaciclib ,  Palbociclib ,  Ribociclib

Terms in the title (8)： アベマシクリブ ,  リソソーム ,  細胞質 ,  液胞 ,  癌細胞 ,  定型 ,  細胞死 ,  誘導