Art

J-GLOBAL ID：202002256064497172   Reference number：20A0977436

Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells

T315I(+)pH+白血病細胞に対するポナチニブ誘発細胞毒性におけるMCL1,c-MycおよびサイクリンD2蛋白質分解の関与【JST・京大機械翻訳】

Author (10)： Inoue Chisato (College of Life and Health Sciences, Chubu University, Kasugai, 487-8501, Japan) ,  Sobue Sayaka (College of Life and Health Sciences, Chubu University, Kasugai, 487-8501, Japan) ,  Kawamoto Yoshiyuki (College of Life and Health Sciences, Chubu University, Kasugai, 487-8501, Japan) ,  Nishizawa Yuji (College of Life and Health Sciences, Chubu University, Kasugai, 487-8501, Japan) ,  Ichihara Masatoshi (College of Life and Health Sciences, Chubu University, Kasugai, 487-8501, Japan) ,  Abe Akihiro (Department of Hematology and Oncology, Fujita Health University, Toyoake, 470-1192, Japan) ,  Hayakawa Fumihiko (Department of Medical Technology, Nagoya University Graduate School of Health Sciences, Nagoya, 461-8673, Japan) ,  Suzuki Motoshi (Department of Molecular Oncology, Fujita Health University, Toyoake, 470-1192, Japan) ,  Nozawa Yoshinori (Tokai Gakuin University, Kakamigahara, 504-8511, Japan) ,  Murate Takahsi (College of Life and Health Sciences, Chubu University, Kasugai, 487-8501, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 525  Issue： 4  Page： 1074-1080  Publication year： 2020 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： T315I mutation found in chroni...

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Thesaurus term： antitumor drug ,  potentiation ,  *Leukemia ,  ischemia ,  *proteolysis ,  varix ,  *cytotoxicity ,  Apoptosis ,  Phosphatidylinositol 3-Kinase ,  Protein Kinase Inhibitors ,  Caspase 3 ,  Proteasome Inhibitor ,  protein expression ,  Glycogen Synthase Kinase 3
Semi thesaurus term： グリコーゲンシンターゼキナーゼ3 , 【Automatic Indexing@JST】

Author keywords (6)： T315I-positive Ph+ leukemia cell ,  Ponatinib ,  MCL1 ,  c-myc ,  Protein degradation ,  MCL1 inhibitors

JST classification (3)： Function of cell components  (EF03060C) ,  Gene expression  (EC02040Q) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Imatinib

Terms in the title (7)： 白血病細胞 ,  ポナチニブ ,  誘発 ,  細胞毒性 ,  c-Myc ,  サイクリンD2 ,  蛋白質分解