Art

J-GLOBAL ID：202002257061581147   Reference number：20A0707784

Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment

Epimedii herbaに含まれるフラボノイド化合物は腫瘍微小環境におけるSTAT3活性化を抑制することにより腫瘍進行を阻害する【JST・京大機械翻訳】

Author (11)： Pan Cheng (Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Fujiwara Yukio (Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Horlad Hasita (Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Shiraishi Daisuke (Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Shiraishi Daisuke (Department of Orthopedic Surgery, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Iriki Toyohisa (Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Iriki Toyohisa (Department of Respiratory Medicine, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Tsuboki Jyunko (Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Tsuboki Jyunko (Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan) ,  Ikeda Tsuyoshi (Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan) ,  Komohara Yoshihiro (Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan)
Material： Frontiers in Pharmacology (Web)
Volume： 11  Page： 262  Publication year： 2020 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： M2-like tumor-associated macro...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A0707784&from=J-GLOBAL&jstjournalNo=U7091A") }}

Thesaurus term： *flavonoid ,  Cell Proliferation ,  targeting ,  Sarcoma ,  human ,  tumor cell ,  interleukin ,  Phenotype ,  macrophage ,  tumorigenesis ,  polarization (phenomenon) ,  animal ,  cancer bearing mouse ,  CD163
Semi thesaurus term： *腫瘍進行 , 【Automatic Indexing@JST】

Author keywords (5)： Epimedii Herba ,  STAT3 ,  flavonoid ,  macrophage ,  tumor cells

JST classification (5)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumor immunity  (ED03040A) ,  Cell physiology in general  (EF02010S) ,  Biophylaxis and immune systems in general  (ED01010F) ,  Basic oncology in general  (GE02010R)

Reference (51)：

• Abou-Ghazal M., Yang D. S., Qiao W., Reina-Ortiz C., Wei J., Kong L. Y., et al (2008). The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas. Clin. Cancer Res. 14 8228-8235. doi: 10.1158/1078-0432.CCR-08-1329
• Bacher M., Brader G., Greger H., Hofer O. (2010). Complete 1H and 13C NMR data assignment of new constituents from Severinia buxifolia. Magn. Reson. Chem. 48 83-88. doi: 10.1002/mrc.2548
• Brantley E. C., Benveniste E. N. (2008). Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol. Cancer Res. 6 675-684. doi: 10.1158/1541-7786.MCR-07-2180
• Chen C. C., Tsai P. C., Wei B. L., Chiou W. F. (2008). 8-Prenylkaempferol suppresses inducible nitric oxide synthase expression through interfering with JNK-mediated AP-1 pathway in murine macrophages. Eur. J. Pharmacol. 590 430-436. doi: 10.1016/j.ejphar.2008.05.018
• Clear A. J., Lee A. M., Calaminici M., Ramsay A. G., Morris K. J., Hallam S., et al (2010). Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting microenvironment. Blood 115 5053-5056. doi: 10.1182/blood-2009-11-253260

Terms in the title (6)： フラボノイド ,  腫瘍微小環境 ,  STAT3 ,  活性化 ,  腫瘍進行 ,  阻害