Art

J-GLOBAL ID：202002258029222415   Reference number：20A2222419

Analysis of T and B Cell Epitopes to Predict the Risk of de novo Donor-Specific Antibody (DSA) Production After Kidney Transplantation: A Two-Center Retrospective Cohort Study

腎臓移植後のde novoドナー特異的抗体(DSA)産生のリスクを予測するためのTおよびB細胞エピトープの解析:2センター後向きコホート研究【JST・京大機械翻訳】

Author (13)： Sakamoto Shintaro (Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Sakamoto Shintaro (Department of Histocompatibility Laboratory, Nagoya Daini Red Cross Hospital, Nagoya, Japan) ,  Iwasaki Kenta (Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Tomosugi Toshihide (Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan) ,  Niemann Matthias (PIRCHE AG, Berlin, Germany) ,  Spierings Eric (Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands) ,  Miwa Yuko (Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Horimi Kosei (Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Takeda Asami (Department of Nephrology, Nagoya Daini Red Cross Hospital, Nagoya, Japan) ,  Goto Norihiko (Department of Transplant Internal Medicine, Nagoya Daini Red Cross Hospital, Nagoya, Japan) ,  Narumi Shunji (Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan) ,  Watarai Yoshihiko (Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan) ,  Kobayashi Takaaki (Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan)
Material： Frontiers in Immunology (Web)
Volume： 11  Page： 2000  Publication year： 2020 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Risk prediction of de novo don...

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Thesaurus term： organ transplantation ,  immunosuppression ,  T cell ,  *kidney transplantation ,  *epitope ,  retrospective cohort study
Semi thesaurus term： *B細胞エピトープ ,  生体臓器提供者 , 【Automatic Indexing@JST】

Author keywords (5)： kidney transplantation ,  eplet mismatch ,  PIRCHE-II ,  donor specific antibody ,  epitope analysis

JST classification (3)： Transplantation immunity  (ED03020E) ,  Blood cell tumors(=neoplasms)  (GK04000M) ,  Surgical treatment for urogenital diseases  (GM05030G)

Reference (42)：

• Terasaki PI, Cai J. Human leukocyte antigen antibodies and chronic rejection: from association to causation. Transplantation. (2008) 86:377-83. doi: 10.1097/TP.0b013e31817c4cb8
• Wan SS, Ying TD, Wyburn K, Roberts DM, Wyld M, Chadban SJ. The treatment of antibody-mediated rejection in kidney transplantation: an updated systematic review and meta-analysis. Transplantation. (2018) 102:557-68. doi: 10.1097/TP.0000000000002049
• Böhmig GA, Eskandary F, Doberer K, Halloran PF. The therapeutic challenge of late antibody-mediated kidney allograft rejection. Transpl Int. (2019) 32:775-88. doi: 10.1111/tri.13436
• Bradley JA, Baldwin WM, Bingaman A, Ellenrieder C, Gebel HM, Glotz D, et al. Antibody-mediated rejection-an ounce of prevention is worth a pound of cure. Am J Transplant. (2011) 11:1131-9. doi: 10.1111/j.1600-6143.2011.03581.x
• Kobayashi T, Maruya E, Niwa M, Saji H, Kohara S, Katayama A, et al. Significant association between chronic antibody-mediated rejection and donor-specific antibodies against HLA-DRB rather than DQB in renal transplantation. Hum Immunol. (2011) 72:11-7. doi: 10.1016/j.humimm.2010.10.018

Terms in the title (9)： 腎臓移植 ,  ドナー特異的抗体 ,  DSA ,  リスク ,  予測 ,  B細胞エピトープ ,  解析 ,  センター ,  後向きコホート研究