Art

J-GLOBAL ID：202002261171582816   Reference number：20A1172324

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

うつ病のゲノムワイドメタ分析は102非依存性変異体を同定し,前頭前野脳領域の重要性を明らかにする【JST・京大機械翻訳】

Author (51)： Howard David M. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Adams Mark J. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Clarke Toni-Kim (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Hafferty Jonathan D. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Gibson Jude (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Shirali Masoud (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Coleman Jonathan R. I. (Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK) ,  Coleman Jonathan R. I. (NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK) ,  Hagenaars Saskia P. (Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK) ,  Hagenaars Saskia P. (NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK) ,  Ward Joey (Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK) ,  Wigmore Eleanor M. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Alloza Clara (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Shen Xueyi (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Barbu Miruna C. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Xu Eileen Y. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Whalley Heather C. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Marioni Riccardo E. (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK) ,  Marioni Riccardo E. (Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK) ,  Porteous David J. (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK) ,  Porteous David J. (Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK) ,  Davies Gail (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK) ,  Davies Gail (Department of Psychology, University of Edinburgh, Edinburgh, UK) ,  Deary Ian J. (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK) ,  Deary Ian J. (Department of Psychology, University of Edinburgh, Edinburgh, UK) ,  Hemani Gibran (Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health, Sciences, Bristol Medical School, University of Bristol, Bristol, UK) ,  Berger Klaus (Institute of Epidemiology & Social Medicine, University of Muenster, Muenster, Germany) ,  Teismann Henning (Institute of Epidemiology & Social Medicine, University of Muenster, Muenster, Germany) ,  Rawal Rajesh (Institute of Epidemiology & Social Medicine, University of Muenster, Muenster, Germany) ,  Arolt Volker (Department of Psychiatry, University of Muenster, Muenster, Germany) ,  Baune Bernhard T. (Department of Psychiatry, University of Melbourne, Victoria, Australia) ,  Dannlowski Udo (Department of Psychiatry, University of Muenster, Muenster, Germany) ,  Domschke Katharina (Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ,  Tian Chao (23andMe, Inc, Mountain View, CA, USA) ,  Hinds David A. (23andMe, Inc, Mountain View, CA, USA) ,  Trzaskowski Maciej (Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia) ,  Byrne Enda M. (Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia) ,  Ripke Stephan (Department of Psychiatry, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Berlin, Germany) ,  Ripke Stephan (Medical and Population Genetics, Broad Institute, Cambridge, MA, USA) ,  Ripke Stephan (Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA) ,  Smith Daniel J. (Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK) ,  Sullivan Patrick F. (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden) ,  Sullivan Patrick F. (Department of Genetics, University of North Carolina, Chapel Hill, NC, USA) ,  Sullivan Patrick F. (Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA) ,  Wray Naomi R. (Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia) ,  Breen Gerome (Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK) ,  Breen Gerome (NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK) ,  Lewis Cathryn M. (Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK) ,  Lewis Cathryn M. (NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK) ,  McIntosh Andrew M. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  McIntosh Andrew M. (Department of Psychology, University of Edinburgh, Edinburgh, UK)
Material： Nature Neuroscience  (Nat Neurosci)
Volume： 22  Issue： 3  Page： 343-352  Publication year： 2019 
JST Material Number： W1370A  ISSN： 1097-6256  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Major depression is ...

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Thesaurus term： neurosis ,  Heredity ,  gene ,  synapse ,  neural transmission ,  psychotic disorder ,  multiplex ,  *depression (disease) ,  computer architecture ,  pathogenesis ,  meta-analysis ,  *prefrontal area ,  *Brain regions ,  *cerebral hemisphere

JST classification (1)： Central nervous system  (EJ12030F)

Terms in the title (9)： うつ病 ,  ゲノム ,  メタ分析 ,  非依存性 ,  変異体 ,  同定 ,  前頭前野 ,  脳領域 ,  重要性