Art

J-GLOBAL ID：202002261201699633   Reference number：20A0486335

FerriIridium: A Lysosome-Targeting Iron(III)-Activated Iridium(III) Prodrug for Chemotherapy in Gastric Cancer Cells

フェリイリジウム:胃癌細胞における化学療法のためのリソソーム標的化鉄(III)活性化イリジウム(III)プロドラッグ【JST・京大機械翻訳】

Author (10)： Kuang Shi (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China) ,  Liao Xinxing (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China) ,  Zhang Xianrui (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China) ,  Rees Thomas W. (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China) ,  Guan Ruilin (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China) ,  Xiong Kai (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China) ,  Chen Yu (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China) ,  Ji Liangnian (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China) ,  Chao Hui (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China) ,  Chao Hui (MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 400201, P. R. China)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 59  Issue： 8  Page： 3315-3321  Publication year： 2020 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Reported is the Fe<sup>III</su...

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Thesaurus term： hydrolysis ,  hydroxyl radical ,  complex(compound) ,  *lysosome ,  catalyst ,  *targeting ,  *drug therapy ,  hydrogen peroxide ,  *stomach tumor ,  *prodrug ,  *tumor cell ,  oxidation ,  amine ,  *iridium
Semi thesaurus term： 呼吸鎖 , 【Automatic Indexing@JST】

Author keywords (5)： bioinorganic chemistry ,  cancer ,  cytotoxicity ,  iridium ,  medicinal chemistry

JST classification (2)： Iron complex  (CE01091H) ,  Crystal structure of complex of iron-group elements  (BK09040I)

Terms in the title (8)： 胃癌細胞 ,  化学療法 ,  リソソーム ,  標的化 ,  鉄 ,  活性化 ,  イリジウム ,  プロドラッグ