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J-GLOBAL ID：202002261359209034   Reference number：20A0706577

Design and Optimization of 3′-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors

選択的DDR1阻害剤としての3′-(イミダゾ[1,2-a]ピラジン-3-イル)-[1,1′-ビフェニル]-3-カルボキサミドの設計と最適化【JST・京大機械翻訳】

Author (13)： Mo Cheng (International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of PR China, College of Pharmacy, Jinan University, China) ,  Mo Cheng (Guangzhou Institutes of Biomedicine and Health, China) ,  Zhang Zhang (International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of PR China, College of Pharmacy, Jinan University, China) ,  Li Yupeng (Guangzhou Institutes of Biomedicine and Health, China) ,  Li Yupeng (Masonic Cancer Center, University of Minnesota, Minnesota, United States) ,  Huang Minhao (Guangzhou Institutes of Biomedicine and Health, China) ,  Zou Jian (International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of PR China, College of Pharmacy, Jinan University, China) ,  Luo Jinfeng (Guangzhou Institutes of Biomedicine and Health, China) ,  Tu Zheng-Chao (Guangzhou Institutes of Biomedicine and Health, China) ,  Xu Yong (Guangzhou Institutes of Biomedicine and Health, China) ,  Ren Xiaomei (International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of PR China, College of Pharmacy, Jinan University, China) ,  Ding Ke (International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of PR China, College of Pharmacy, Jinan University, China) ,  Lu Xiaoyun (International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of PR China, College of Pharmacy, Jinan University, China)
Material： ACS Medicinal Chemistry Letters
Volume： 11  Issue： 3  Page： 379-384  Publication year： 2020 
JST Material Number： W5043A  ISSN： 1948-5875  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： DDR1 is considered as a promis...

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Thesaurus term： non-small cell lung cancer ,  tumorigenesis ,  *optimization
Semi thesaurus term： 阻害活性 ,  DDR2 ,  キナーゼ ,  癌治療 ,  *DDR1 , 【Automatic Indexing@JST】

Author keywords (5)： DDR1 ,  selective inhibitor ,  NSCLC ,  drug discovery ,  SAR

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Terms in the title (7)： DDR1 ,  阻害剤 ,  ピラジン ,  ビフェニル ,  カルボキサミド ,  設計 ,  最適化