Art

J-GLOBAL ID：202002261446775123   Reference number：20A1354445

Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species

ラット,イヌ,ヒトにおけるナリンギンおよび活性代謝物ナリンゲニンの薬物動態と代謝,および種間の差異【JST・京大機械翻訳】

Author (20)： Bai Yang (Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-Marketed Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Bai Yang (Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Peng Wei (Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-Marketed Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Peng Wei (Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Yang Cuiping (Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-Marketed Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Yang Cuiping (Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Zou Wei (Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-Marketed Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Zou Wei (Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Liu Menghua (Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-Marketed Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Liu Menghua (Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Wu Hao (Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-Marketed Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Wu Hao (Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Fan Loudi (Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-Marketed Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Fan Loudi (Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Li Peibo (Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-Marketed Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Li Peibo (Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Zeng Xuan (Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-Marketed Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Zeng Xuan (Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Su Weiwei (Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-Marketed Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China) ,  Su Weiwei (Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China)
Material： Frontiers in Pharmacology (Web)
Volume： 11  Page： 364  Publication year： 2020 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Background: Pharmacokinetics p...

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Thesaurus term： food ,  enzyme ,  intravenous administration ,  *metabolite ,  bioassay ,  human ,  *Rattus ,  clinical trial ,  microsome ,  single administration ,  herb ,  liquid chromatography-tandem mass spectrometry ,  *Myomorpha ,  phenolic compound ,  oxygen heterocyclic compound ,  glycoside (except carbohydrate) ,  deoxysugar ,  disaccharide ,  flavonoid ,  mannoside ,  glucoside ,  polynuclear aromatic compound ,  hydroxy ketone ,  aromatic ketone ,  polyphenol
Semi thesaurus term： LC/MS/MS , 【Automatic Indexing@JST】

Author keywords (8)： pharmacokinetics ,  metabolism ,  rat ,  dog ,  human ,  naringin ,  naringenin ,  species differences

JST classification (2)： Clinical biopharmacy  (GY01022L) ,  Interactions of drugs  (GV01070X)

Substance index (2)： Naringin ,  Naringenin

Reference (34)：

• Chen Y., Nie Y. C., Luo Y. L., Lin F., Zheng Y. F., Cheng G. H., et al. (2013). Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. Food. Chem. Toxicol. 58, 133-140. doi: doi: 10.1016/j.fct.2013.04.024
• Chen Y., Wu H., Nie Y. C., Li P. B., Shen J. G., Su W. W. (2014). Mucoactive effects of naringin in lipopolysaccharide-induced acute lung injury mice and beagle dogs. Environ. Toxicol. Pharmacol. 38, 279-287. doi: doi: 10.1016/j.etap.2014.04.030
• Chen T., Su W., Yan Z., Wu H., Zeng X., Peng W., et al. (2018). Identification of naringin metabolites mediated by human intestinal microbes with stable isotope-labeling method and UFLC-Q-TOF-MS/MS. J. Pharm. Biomed. Anal. 161, 262-272. doi: doi: 10.1016/j.jpba.2018.08.039
• Chinese Pharmacopoeia Commission. (2015). Pharmacopoeia of the People’s Republic of China. Edition 2015. (Beijing: China Medical Sciences Press). doi: 10.1016/j.jpba.2018.08.039
• Gao S., Li P., Yang H., Fang S., Su W. (2011). Antitussive effect of naringin on experimentally induced cough in Guinea pigs. Planta Med. 77, 16-21. doi: doi: 10.1055/s-0030-1250117

Terms in the title (9)： ラット ,  イヌ ,  ヒト ,  ナリンギン ,  活性代謝物 ,  ナリンゲニン ,  薬物動態 ,  代謝 ,  差異