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J-GLOBAL ID：202002261928086689   Reference number：20A0554273

Mutant ASXL1 activates Akt/mTOR signaling and alters physiological aging of hematopoietic stem cells

変異ASXL1はAkt/mTORシグナル伝達を活性化し,造血幹細胞の生理的老化を変化させる
Author (23)：
FUJINO Takeshi

About FUJINO Takeshi

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
GOYAMA Susumu

About GOYAMA Susumu

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
SUGIURA Yuki

About SUGIURA Yuki

(Dep. of Biochemistry, Keio Univ., Tokyo, JPN)

About Dep. of Biochemistry, Keio Univ., Tokyo, JPN

, 
INOUE Daichi

About INOUE Daichi

(Memorial Sloan-Kettering Cancer Center, New York, USA)

About Memorial Sloan-Kettering Cancer Center, New York, USA

, 
TSUCHIYA Akiho

About TSUCHIYA Akiho

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
YAMASAKI Satoshi

About YAMASAKI Satoshi

(Lab. of Molecular Medicine, Tokyo Univ., Tokyo, JPN)

About Lab. of Molecular Medicine, Tokyo Univ., Tokyo, JPN

, 
MATSUMOTO Akiko

About MATSUMOTO Akiko

(Lab. of Molecular Medicine, Tokyo Univ., Tokyo, JPN)

About Lab. of Molecular Medicine, Tokyo Univ., Tokyo, JPN

, 
SATO Naru

About SATO Naru

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
ASADA Shuhei

About ASADA Shuhei

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
MORINAGA Hironobu

About MORINAGA Hironobu

(Stem Cell Biology, Tokyo Medical and Dental Univ., JPN)

About Stem Cell Biology, Tokyo Medical and Dental Univ., JPN

, 
SHIKATA Shiori

About SHIKATA Shiori

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
NAGASE Reina

About NAGASE Reina

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
FUKUYAMA Tomofusa

About FUKUYAMA Tomofusa

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
TANAKA Yosuke

About TANAKA Yosuke

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
FUKUSHIMA Tsuyoshi

About FUKUSHIMA Tsuyoshi

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
TAKEDA Reina

About TAKEDA Reina

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
YAMAMOTO Keita

About YAMAMOTO Keita

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN

, 
HONDA Hiroaki

About HONDA Hiroaki

(Field of Human Disease Models, Tokyo Women’s Medical Univ., JPN)

About Field of Human Disease Models, Tokyo Women’s Medical Univ., JPN

, 
NISHIMURA Emi

About NISHIMURA Emi

(Stem Cell Biology, Tokyo Medical and Dental Univ., JPN)

About Stem Cell Biology, Tokyo Medical and Dental Univ., JPN

, 
SHIBATA Tatsuhiro

About SHIBATA Tatsuhiro

(Lab. of Molecular Medicine, Tokyo Univ., Tokyo, JPN)

About Lab. of Molecular Medicine, Tokyo Univ., Tokyo, JPN

, 
ABDEL-WAHAB Omar

About ABDEL-WAHAB Omar

(Memorial Sloan-Kettering Cancer Center, New York, USA)

About Memorial Sloan-Kettering Cancer Center, New York, USA

, 
SUEMATSU Makoto

About SUEMATSU Makoto

(Dep. of Biochemistry, Keio Univ., Tokyo, JPN)

About Dep. of Biochemistry, Keio Univ., Tokyo, JPN

, 
KITAMURA Toshio

About KITAMURA Toshio

(Div. of Cellular Therapy, Tokyo Univ., JPN)

About Div. of Cellular Therapy, Tokyo Univ., JPN


Material：
日本血液学会学術集会抄録(Web)  (日本血液学会学術集会(Web))

About 日本血液学会学術集会抄録(Web)


Volume： 81st  Page： S175 (WEB ONLY)  Publication year： 2019 
JST Material Number： U1761A  Document type： Proceedings
Article type： 会議録記事  Country of issue： Japan (JPN)  Language： ENGLISH (EN)
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gene

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,...
Semi thesaurus term：
Thesaurus term/Semi thesaurus term
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All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
cellular signal transduction

About cellular signal transduction

,...
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JST classification (3)：
JST classification
Category name(code) classified by JST.
Hematopoietic system 
(EJ07020Y)

About Hematopoietic system

,  Basic hematology 
(GK01020N)

About Basic hematology

,  Genetic variation 
(EC01030Y)

About Genetic variation

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
Sirolimus

About Sirolimus

Terms in the title (8)：
Terms in the title
Keywords automatically extracted from the title.
変異

About 変異

, 
AKT

About AKT

, 
mTOR

About mTOR

, 
シグナル伝達

About シグナル伝達

, 
活性化

About 活性化

, 
造血幹細胞

About 造血幹細胞

, 
生理

About 生理

, 
老化

About 老化


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