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J-GLOBAL ID：202002263712329126   Reference number：20A0877751

Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NFκB activation and apoptosis in an AAA+ domain-dependent manner

RNF213の環ドメインにおけるモヤモヤ病患者突然変異はそのユビキチンリガーゼ活性を低下させ,AAA+ドメイン依存的にNFκB活性化とアポトーシスを増強する【JST・京大機械翻訳】

Author (16)： Takeda Midori (Laboratory of Molecular Biosciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Takeda Midori (Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Tezuka Tohru (Laboratory of Molecular Biosciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Tezuka Tohru (Human Biosciences Unit for the Top Global Course, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan) ,  Kim Minsoo (The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan) ,  Choi Jungmi (Laboratory of Molecular Biosciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Choi Jungmi (Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Oichi Yuki (Laboratory of Molecular Biosciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Oichi Yuki (Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Kobayashi Hatasu (Department of Environmental and Molecular Medicine, Graduate School of Medicine, Mie University, Mie, Japan) ,  Harada Kouji H. (Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Mizushima Tsunehiro (Graduate School of Life Science, University of Hyogo, Hyogo, Japan) ,  Taketani Shigeru (Laboratory of Molecular Biosciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Koizumi Akio (Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Koizumi Akio (Institute of Public Health and Welfare Research, Kyoto, Japan) ,  Youssefian Shohab (Laboratory of Molecular Biosciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 525  Issue： 3  Page： 668-674  Publication year： 2020 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Moyamoya disease (MMD) is a ce...

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Thesaurus term： ATPase ,  *Moyamoya Disease ,  characterization ,  Proteins ,  cerebrovascular disorder ,  *Apoptosis ,  *NF-kappaB ,  *Mutation ,  Ubiquitination ,  in vitro experiment ,  internal carotid artery ,  overexpression ,  HEK293T cell ,  Polyubiquitin ,  *domain structure

Author keywords (6)： Moyamoya disease ,  RNF213 ,  Ubiquitin ligase ,  Ubiquitination ,  NFκB ,  Apoptosis

JST classification (1)： Cell components in general  (EF03010Z)

Terms in the title (11)： ドメイン ,  モヤモヤ病 ,  患者 ,  突然変異 ,  ユビキチンリガーゼ ,  活性 ,  AAA+ ,  NFκB ,  活性化 ,  アポトーシス ,  増強