Art

J-GLOBAL ID：202002265444827040   Reference number：20A0478998

A novel series of cysteine-dependent, allosteric inverse agonists of the nuclear receptor RORγt

核受容体Rorγtのシステイン依存性アロステリック逆作動薬の新規シリーズ【JST・京大機械翻訳】

Author (13)： Jiang Xin (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA) ,  Dulubova Irina (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA) ,  Reisman Scott A. (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA) ,  Hotema Martha (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA) ,  Lee Chun-Yue I. (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA) ,  Liu Liping (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA) ,  McCauley Lyndsey (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA) ,  Trevino Isaac (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA) ,  Ferguson Deborah A. (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA) ,  Eken Yigitcan (Department of Chemistry, Michigan State University, 578 South Shaw Lane, East Lansing, MI 48824, USA) ,  Wilson Angela K. (Department of Chemistry, Michigan State University, 578 South Shaw Lane, East Lansing, MI 48824, USA) ,  Wigley W. Christian (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA) ,  Visnick Melean (Reata Pharmaceuticals, Inc., 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 30  Issue： 6  Page： Null  Publication year： 2020 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Inhibition of the nuclear rece...

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Thesaurus term： site-directed mutagenesis ,  retinoic acid receptor ,  differentiation(biology) ,  interleukin ,  autoimmune disease ,  rheumatoid arthritis ,  *human(primates) ,  modulator ,  aliphatic amine ,  thiol ,  aliphatic carboxylic acid ,  sulfur containing amino acid ,  primary amine
Semi thesaurus term： Th17細胞 ,  CD4陽性T細胞 ,  αヘリックス ,  リガンド結合ドメイン ,  RORγt ,  *核内受容体 , 【Automatic Indexing@JST】

Author keywords (6)： RORgγt inverse agonists ,  IL-17 ,  Autoimmune disease ,  Th17 cell differentiation ,  Molecular dynamics simulations ,  Allosteric NR modulator

JST classification (2)： Synthesis of drugs  (GV01030F) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (1)： Cysteine

Terms in the title (5)： 核受容体 ,  RORγt ,  システイン ,  依存性 ,  逆作動薬