Art

J-GLOBAL ID：202002266982025763   Reference number：20A2212129

Oncogenic mutation in RAS-RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer

RAS-RAF軸における発癌性変異はGREB1の発現を増加させ,結腸直腸癌の腫瘍増殖を引き起こす

Author (16)： Kochi Masatoshi (Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Hinoi Takao (Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Hinoi Takao (Department of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan) ,  Hinoi Takao (Department of Clinical and Molecular Genetics, Hiroshima University Hospital, Hiroshima, Japan) ,  Niitsu Hiroaki (Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA) ,  Miguchi Masashi (Department of Gastroenterological, Breast and Transplant Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan) ,  Saito Yasufumi (Department of Surgery, Chugoku Rosai Hospital, Hiroshima, Japan) ,  Sada Haruki (Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Sada Haruki (Department of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan) ,  Sentani Kazuhiro (Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan) ,  Sakamoto Naoya (Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan) ,  Oue Naohide (Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan) ,  Tashiro Hirotaka (Department of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan) ,  Sotomaru Yusuke (Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan) ,  Yasui Wataru (Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan) ,  Ohdan Hideki (Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 111  Issue： 10  Page： 3540-3549  Publication year： 2020 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： BRAF gene ,...

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Author keywords (5)： BRAF mutation ,  colorectal cancer ,  ER ,  GREB1 ,  mouse model

JST classification (2)： Carcinogenic mechanisms and factors  (GE02020C) ,  Gene expression  (EC02040Q)

Terms in the title (7)： Ras ,  Raf ,  発癌性 ,  変異 ,  発現 ,  結腸直腸癌 ,  腫瘍増殖