Art

J-GLOBAL ID：202002268004724070   Reference number：20A0577667

Design, synthesis and biological activity of N ⁵ -substituted tetrahydropteroate analogs as non-classical antifolates against cobalamin-dependent methionine synthase and potential anticancer agents

コバラミン依存性メチオニンシンターゼおよび潜在的抗癌剤に対する非古典的抗葉酸剤としてのN5-置換テトラヒドロプテロアート類似体の設計,合成および生物活性【JST・京大機械翻訳】

Author (15)： Wang Meng (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Wang Meng (College of Pharmacy, Beihua University, Jilin, 132013, China) ,  Tian Chao (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Xue Liangmin (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Li Hao (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Cong Jing (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Fang Fang (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Yang Jiajia (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Yuan Mengmeng (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Chen Ying (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Guo Ying (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Wang Xiaowei (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Liu Junyi (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China) ,  Liu Junyi (State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China) ,  Zhang Zhili (Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China)
Material： European Journal of Medicinal Chemistry  (Eur J Med Chem)
Volume： 190  Page： Null  Publication year： 2020 
JST Material Number： E0845A  ISSN： 0223-5234  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Cobalamin-dependent methionine...

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Thesaurus term： structure-activity relationship ,  tumor cell ,  monophase ,  analogical material ,  *biological activity ,  *antitumor drug ,  HL60 cell ,  apoptosis ,  cytotoxicity ,  electrophilic substitution reaction ,  human(primates) ,  *methionine synthase ,  *folic acid antagonist ,  flow cytometry ,  *antineoplastic antimetabolite
Semi thesaurus term： *コバラミン , 【Automatic Indexing@JST】

Author keywords (5)： Pyrido[3 2-d]pyrimidine ,  Methionine synthase ,  Antifolate ,  Inhibitor ,  Anticancer

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Enzyme in general  (EB09010D)

Terms in the title (9)： コバラミン ,  依存性 ,  メチオニンシンターゼ ,  抗癌剤 ,  抗葉酸剤 ,  置換 ,  類似体 ,  設計 ,  生物活性