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J-GLOBAL ID：202002268709600431   Reference number：20A1777978

ROCK Inhibition May Stop Diabetic Kidney Disease

ROCK阻害は糖尿病性腎疾患を停止させる可能性がある

Author (8)： MATOBA Keiichiro (Jikei Univ. School of Medicine, Tokyo, JPN) ,  TAKEDA Yusuke (Jikei Univ. School of Medicine, Tokyo, JPN) ,  NAGAI Yosuke (Jikei Univ. School of Medicine, Tokyo, JPN) ,  KANAZAWA Yasushi (Jikei Univ. School of Medicine, Tokyo, JPN) ,  KAWANAMI Daiji (Fukuoka Univ. School of Medicine, Fukuoka, JPN) ,  YOKOTA Tamotsu (Jikei Univ. School of Medicine, Tokyo, JPN) ,  UTSUNOMIYA Kazunori (Jikei Univ. School of Medicine, Tokyo, JPN) ,  NISHIMURA Rimei (Jikei Univ. School of Medicine, Tokyo, JPN)
Material： JMA Journal (Web)
Volume： 3  Issue： 3  Page： 154-163 (WEB ONLY)  Publication year： Jul. 15, 2020 
JST Material Number： U0643B  ISSN： 2433-3298  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *diabetic nephropathy ,...
Semi thesaurus term： *Rho kinase ,...

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JST classification (2)： Basic medicine on urogenital system  (GM01020T) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Reference (67)：

• 1. Kingma JG Jr, Simard D, Rouleau JR. Renocardiac syndromes: physiopathology and treatment stratagems. Can J Kidney Health Dis. 2015;2:41.
• 2. Adler AI, Stevens RJ, Manley SE, et al. Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney Int. 2003;63 (1):225-32.
• 3. Kawanami D, Matoba K, Utsunomiya K. Signaling pathways in diabetic nephropathy. Histol Histopathol. 2016;31 (10):1059-67.
• 4. Gaede P, Lund-Andersen H, Parving HH, et al. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008;358 (6):580-91.
• 5. Ueki K, Sasako T, Okazaki Y, et al. Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2017;5 (12):951-64.

Terms in the title (4)： ROCK ,  阻害 ,  糖尿病性腎疾患 ,  可能性