Art

J-GLOBAL ID：202002268927640619   Reference number：20A0764494

(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression

(S)-ノルケタミンおよび(2S,6S)-hydroxynケタミンはうつ病の慢性コルチコステロン誘発マウスモデルにおいて強力な抗うつ様効果を発揮する【JST・京大機械翻訳】

Author (24)： Yokoyama Rei (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Higuchi Momoko (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Tanabe Wataru (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Tsukada Shinji (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Naito Megumi (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Yamaguchi Takumi (Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Chen Lu (Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Kasai Atsushi (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Seiriki Kaoru (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Seiriki Kaoru (Interdisciplinary Program for Biomedical Sciences, Institute for Transdisciplinary Graduate Degree Programs, Osaka University, Suita, Osaka 565-0871, Japan) ,  Nakazawa Takanobu (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Nakazawa Takanobu (Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565-0871, Japan) ,  Nakagawa Shinsaku (Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Nakagawa Shinsaku (Laboratory of Innovative Food Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Nakagawa Shinsaku (Global Center for Medical Engineering and Informatics, Osaka University, Suita, Osaka 565-0871, Japan) ,  Hashimoto Kenji (Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan) ,  Hashimoto Hitoshi (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Hashimoto Hitoshi (Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka 565-0871, Japan) ,  Hashimoto Hitoshi (Division of Bioscience, Institute for Datability Science, Osaka University, Suita, Osaka 565-0871, Japan) ,  Hashimoto Hitoshi (Transdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka 565-0871, Japan) ,  Hashimoto Hitoshi (Department of Molecular Pharmaceutical Science, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan) ,  Ago Yukio (Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Ago Yukio (Laboratory of Innovative Food Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan) ,  Ago Yukio (Global Center for Medical Engineering and Informatics, Osaka University, Suita, Osaka 565-0871, Japan)
Material： Pharmacology Biochemistry and Behavior  (Pharmacol Biochem Behav)
Volume： 191  Page： Null  Publication year： 2020 
JST Material Number： H0398B  ISSN： 0091-3057  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Clinical and preclinical studi...

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Thesaurus term： antidepressant action ,  antidepressive drug ,  metabolite ,  anemia ,  Rodentia ,  *depression(disease) ,  *depression(symptom) ,  edentulous mouth ,  single administration ,  aromatic chlorine compound ,  alicyclic ketone ,  secondary amine ,  steroid ,  enone ,  alicyclic alcohol ,  diol ,  diketone ,  secondary alcohol ,  hydroxy ketone
Semi thesaurus term： 強制水泳試験 ,  アンタゴニスト ,  用量依存性 ,  *マウスモデル , 【Automatic Indexing@JST】

Author keywords (6)： Ketamine metabolites ,  Depression model ,  Antidepressant ,  Anti-anhedonic ,  Behaviors ,  C57BL/6J mice

JST classification (1)： Basic research of psychotropic drugs  (GW03100Y)

Substance index (2)： Ketamine ,  Corticosterone

Terms in the title (8)： ノルケタミン ,  ケタミン ,  うつ病 ,  慢性 ,  コルチコステロン ,  誘発 ,  マウスモデル ,  うつ