Art

J-GLOBAL ID：202002269004643102   Reference number：20A0365097

Remyelination therapy for multiple sclerosis-Current status and future perspectives

多発性硬化症の髄鞘再生療法-現状と課題-

Author (1)： NAKAHARA JIN (慶應義塾大学医学部神経内科)
Material： 神経治療学(Web)  (Neurological Therapeutics (Web))
Volume： 36  Issue： 3  Page： 214-216(J-STAGE)  Publication year： 2019 
JST Material Number： U0830A  ISSN： 2189-7824  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human(primates) ,...
Semi thesaurus term： オピシヌマブ ,...

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Author keywords (6)： multiple sclerosis ,  oligodendrocyte ,  remyelination therapy ,  multiple sclerosis ,  oligodendrocyte ,  remyelination therapy

JST classification (1)： Drug therapy(=pharmacotherapy)for nervous system diseases  (GN05020Y)

Reference (15)：

• 1) De Stefano N, Giorgio A, Battaglini M et al : Assessing brain atrophy rate in a large population of untreated multiple sclerosis subtypes. Neurology 74 : 1868-1876, 2010
• 2) Goldschmidt T, Antel J, König FB et al : Remyelination capacity of the MS brain decreases with disease chronicity. Neurology 72 : 1914-1921, 2009
• 3) Lee Y, Morrison BM, Li Y et al : Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature 487 : 443-448, 2012
• 4) Kang SH, Li Y, Fukaya M et al : Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci 16 : 571-579, 2013
• 5) Agosta F, Rovaris M, Pagani E et al : Magnetization transfer MRI metrics predict the accumulation of disability 8 years later in patients with multiple sclerosis. Brain 129 : 2620-2627, 2006

Terms in the title (4)： 多発性硬化症 ,  髄鞘 ,  再生療法 ,  現状