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J-GLOBAL ID：202002269094744307   Reference number：20A1441696

CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice

抑制性ニューロンにおけるCRISPR/dCas9に基づくScn1a遺伝子活性化は,Dravet症候群モデルマウスのてんかんおよび行動表現型を改善する【JST・京大機械翻訳】

Author (14)： Yamagata Tetsushi (Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Yamagata Tetsushi (Department of Neurodevelopmental Disorder Genetics, Institute of Brain Sciences, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan) ,  Raveau Matthieu (Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Kobayashi Kenta (Section of Viral Vector Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan) ,  Kobayashi Kenta (Graduate University for Advanced Studies (SOKENDAI), Hayama 240-0193, Japan) ,  Miyamoto Hiroyuki (Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Miyamoto Hiroyuki (International Research Center for Neurointelligence (IRCN), The University of Tokyo Institutes for Advanced Study, Tokyo 113-0033, Japan) ,  Tatsukawa Tetsuya (Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Ogiwara Ikuo (Department of Physiology, Nippon Medical School, Tokyo 113-8602, Japan) ,  Itohara Shigeyoshi (Laboratory for Behavioral Genetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Itohara Shigeyoshi (FIRST, Japan Science and Technology Agency, Saitama 332-0012, Japan) ,  Hensch Takao K. (International Research Center for Neurointelligence (IRCN), The University of Tokyo Institutes for Advanced Study, Tokyo 113-0033, Japan) ,  Yamakawa Kazuhiro (Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan) ,  Yamakawa Kazuhiro (Department of Neurodevelopmental Disorder Genetics, Institute of Brain Sciences, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan)
Material： Neurobiology of Disease  (Neurobiol Dis)
Volume： 141  Page： Null  Publication year： 2020 
JST Material Number： W1774A  ISSN： 0969-9961  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Dravet syndrome is a severe in...

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Thesaurus term： *neuron ,  *gene ,  *epilepsy ,  nuclease ,  human(primates) ,  *phenotype ,  cultured cell ,  promoter(genetics) ,  parvalbumin ,  gene therapy ,  seizure(disease) ,  transgenic mouse ,  up-regulation ,  in vitro experiment
Semi thesaurus term： *Cas9 , 【Automatic Indexing@JST】

JST classification (2)： Basic neurology  (GN01020W) ,  Gene manipulation  (EC02050B)

Terms in the title (9)： 抑制性ニューロン ,  CRISPR ,  SCN1A遺伝子 ,  活性化 ,  Dravet症候群 ,  モデルマウス ,  てんかん ,  行動 ,  表現型