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J-GLOBAL ID：202002269152939728   Reference number：20A2465317

Tumor-like features of gene expression and metabolic profiles in enlarged pancreatic islets are associated with impaired incretin-induced insulin secretion in obese diabetes: A study of Zucker fatty diabetes mellitus rat

肥大膵島における遺伝子発現と代謝プロファイルの腫瘍様特徴は肥満糖尿病におけるインクレチン誘導インスリン分泌障害と関連する:Zucker糖尿病ラットの研究

Author (21)： Hayami Tomohide (Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Hayami Tomohide (Kansai Electric Power Medical Research Institute, Kobe, Japan) ,  Hayami Tomohide (Division of Diabetes, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan) ,  Yokoi Norihide (Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Yokoi Norihide (Kansai Electric Power Medical Research Institute, Kobe, Japan) ,  Yamaguchi Takuro (Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Yamaguchi Takuro (Kansai Electric Power Medical Research Institute, Kobe, Japan) ,  Honda Kohei (Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Murao Naoya (Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Takahashi Harumi (Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Takahashi Harumi (Kansai Electric Power Medical Research Institute, Kobe, Japan) ,  Wang Shujie (Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Tsu, Japan) ,  Seino Yusuke (Division of Endocrinology and Metabolism, Department of Internal Medicine, Fujita Health University, Toyoake, Japan) ,  Kamiya Hideki (Division of Diabetes, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan) ,  Yabe Daisuke (Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Yabe Daisuke (Kansai Electric Power Medical Research Institute, Kobe, Japan) ,  Sweet Ian R (Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington, USA) ,  Mizoguchi Akira (Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Tsu, Japan) ,  Nakamura Jiro (Division of Diabetes, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan) ,  Seino Susumu (Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Seino Susumu (Kansai Electric Power Medical Research Institute, Kobe, Japan)
Material： Journal of Diabetes Investigation (Web)  (JDI (Web))
Volume： 11  Issue： 6  Page： 1434-1447  Publication year： 2020 
JST Material Number： U0507A  ISSN： 2040-1124  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： Zucker diabetic fatty rat ,...

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Author keywords (3)： Enlarged islets ,  Incretin ,  Tumor cells

JST classification (5)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Basic medicine on digestive system  (GH01020E) ,  Basic medicine on endocrine system  (GL01020Q) ,  Pancreas  (EJ06050Y) ,  Metabolism and nutrition of sugar(=glucide)  (EJ02035H)

Terms in the title (11)： 肥大 ,  膵島 ,  遺伝子発現 ,  代謝プロファイル ,  腫瘍 ,  肥満糖尿病 ,  インクレチン ,  誘導 ,  インスリン分泌障害 ,  糖尿病ラット ,  研究