Art

J-GLOBAL ID：202002269757287387   Reference number：20A1297226

Identification of a Novel Deactivating Small-Molecule Compound for Fibrogenic Hepatic Stellate Cells

線維形成性肝星細胞に対する新しい脱活性化小分子化合物の同定

Author (7)： Sakaguchi Takuki (Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medical Sciences, Tottori University, Yonago 683-8503, Japan) ,  Sakaguchi Takuki (Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan) ,  Kono Yohei (Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medical Sciences, Tottori University, Yonago 683-8503, Japan) ,  Itaba Noriko (Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medical Sciences, Tottori University, Yonago 683-8503, Japan) ,  Morimoto Minoru (Research Initiative Center, Tottori University, Tottori 680-8550, Japan) ,  Isomoto Hajime (Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan) ,  Shiota Goshi (Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medical Sciences, Tottori University, Yonago 683-8503, Japan)
Material： Yonago Acta Medica (Web)  (Yonago Acta Med (Web))
Volume： 63  Issue： 1  Page： 79-87(J-STAGE)  Publication year： 2020 
JST Material Number： U0588A  ISSN： 1346-8049  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： cellular signal transduction ,...

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Author keywords (4)： deactivation ,  hepatic stellate cells ,  liver fibrosis ,  small-molecule compound

JST classification (2)： Basic research of drugs acting on digestive system  (GW09010Q) ,  Basic medicine on digestive system  (GH01020E)

Substance index (1)： IC-2

Reference (21)：

• 1. Higashi T, Friedman SL, Hoshida Y. Hepatic stellate cells as key target in liver fibrosis. Adv Drug Deliv Rev. 2017;121:27-42. PMID:28506744, DOI:10.1016/j.addr.2017.05.007
• 2. Forouzanfar MH, Alexander L, Anderson HR, Bachman VF, Biryukov S, Brauer M, et al.; GBD 2013 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386:2287-323. PMID:26364544, DOI:10.1016/S0140-6736(15)00128-2
• 3. Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet. 2014;383:1749-61. PMID:24480518, DOI:10.1016/S0140-6736(14)60121-5
• 4. Friedman SL, Sheppard D, Duffield JS, Violette S. Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med. 2013;5:167sr1. PMID:23303606, DOI:10.1126/scitranslmed.3004700
• 5. Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev. 2008;88:125-72. PMID:18195085, DOI:10.1152/physrev.00013.2007

Terms in the title (5)： 線維形成 ,  肝星細胞 ,  脱活性化 ,  分子化合物 ,  同定