Art
J-GLOBAL ID：202002269989695506   Reference number：20A1524903

Functional characterization of a unique mutant of ALK2, p.K400E, that is associated with a skeletal disorder, diffuse idiopathic skeletal hyperostosis

骨格障害,びまん性特発性骨過形成症と関連するALK2,p.K400Eのユニークな変異体の機能的特性化【JST・京大機械翻訳】
Author (5)：
Tsukamoto Sho

About Tsukamoto Sho

(Division of Biomedical Sciences, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1241, Japan)

About Division of Biomedical Sciences, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1241, Japan

, 
Tsukamoto Sho

About Tsukamoto Sho

(Project of Clinical and Basic Research for FOP, Saitama Medical University, Saitama, Japan)

About Project of Clinical and Basic Research for FOP, Saitama Medical University, Saitama, Japan

, 
Kuratani Mai

About Kuratani Mai

(Division of Biomedical Sciences, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1241, Japan)

About Division of Biomedical Sciences, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1241, Japan

, 
Katagiri Takenobu

About Katagiri Takenobu

(Division of Biomedical Sciences, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1241, Japan)

About Division of Biomedical Sciences, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1241, Japan

, 
Katagiri Takenobu

About Katagiri Takenobu

(Project of Clinical and Basic Research for FOP, Saitama Medical University, Saitama, Japan)

About Project of Clinical and Basic Research for FOP, Saitama Medical University, Saitama, Japan


Material：
Bone (New York)  (Bone (N.Y.))

About Bone (New York)


Volume： 137  Page： Null  Publication year： 2020 
JST Material Number： E0177D  ISSN： 8756-3282  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
All summary is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
Bone morphogenetic protein (BM...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
osteogenesis

About osteogenesis

, 
receptor

About receptor

, 
ligaments

About ligaments

, 
Spinal Cord

About Spinal Cord

, 
calcification

About calcification

, 
phosphorylation

About phosphorylation

, 
*hyperplasia

About hyperplasia

, 
characterization

About characterization

, 
in vitro experiment

About in vitro experiment

, 
serine-threonine kinase

About serine-threonine kinase

, 
osteogenic factor

About osteogenic factor

, 
receptor kinase

About receptor kinase

, 
co-expression

About co-expression

, 
overexpression

About overexpression

, 
Signal Transduction

About Signal Transduction


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
cellular signal transduction

About cellular signal transduction

, 【Automatic Indexing@JST】
Author keywords (4)：
Diffuse idiopathic skeletal hyperostosis

About Diffuse idiopathic skeletal hyperostosis

, 
Activin receptor-like kinase 2 (ALK2)

About Activin receptor-like kinase 2 (ALK2)

, 
BMP signaling

About BMP signaling

, 
Skeletal disorder

About Skeletal disorder

JST classification (5)：
JST classification
Category name(code) classified by JST.
Musculoskeletal diseases 
(GG03000T)

About Musculoskeletal diseases

,  Biological function 
(EB03040U)

About Biological function

,  Receptors on cell membrane 
(EF04030C)

About Receptors on cell membrane

,  Congenital diseases,deformities in general. 
(GD03010V)

About Congenital diseases,deformities in general.

,  Basic medicine on musculoskeletal system 
(GG01020B)

About Basic medicine on musculoskeletal system

Terms in the title (5)：
Terms in the title
Keywords automatically extracted from the title.
骨格障害

About 骨格障害

, 
骨過形成症

About 骨過形成症

, 
ALK2

About ALK2

, 
変異体

About 変異体

, 
特性化

About 特性化


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