Art

J-GLOBAL ID：202002270534265533   Reference number：20A0768734

Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages

スコパロンはマクロファージにおけるROS/p38/Nrf2軸およびPI3K/Akt/mTOR経路を調節することにより非アルコール性脂肪肝炎のマウスにおける肝炎症およびオートファジーを改善する【JST・京大機械翻訳】

Author (8)： Liu Beibei (Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China) ,  Deng Xiaoling (Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China) ,  Jiang Qianqian (Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China) ,  Li Guixin (Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China) ,  Zhang Junli (Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China) ,  Zhang Ning (Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China) ,  Xin Shengliang (Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China) ,  Xu Keshu (Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China)
Material： Biomedicine & Pharmacotherapy  (Biomedicine and Pharmacotherapy)
Volume： 125  Page： Null  Publication year： 2020 
JST Material Number： A0845C  ISSN： 0753-3322  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Scoparone has been shown to am...

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Thesaurus term： *inflammation ,  *hepatitis ,  substrate(biochemistry) ,  anti-inflammatory action ,  lipopolysaccharide ,  *macrophage ,  up-regulation ,  in vitro experiment ,  hepatocyte ,  *phosphatidylinositol 3-kinase ,  *autophagy
Semi thesaurus term： *P38 ,  p62 ,  *NFE2関連因子2 ,  炎症反応 , 【Automatic Indexing@JST】

Author keywords (5)： NASH ,  Scoparone ,  Macrophage ,  Inflammation ,  Autophagy

JST classification (1)： Basic medicine on digestive system  (GH01020E)

Terms in the title (14)： スコパロン ,  マクロファージ ,  ROS ,  P38 ,  NRF2 ,  PI3K ,  Akt ,  mTOR ,  経路 ,  調節 ,  非アルコール性脂肪肝炎 ,  マウス ,  肝炎症 ,  オートファジー