Art

J-GLOBAL ID：202002273289496756   Reference number：20A2015550

Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol

セロトニン4受容体PET脳イメージング,機能的MRI,認知,EEGベースおよび末梢バイオマーカーを用いたMajorうつ病性障害における治療転帰の予測:NeuroPharmオープンラベル臨床試験プロトコル【JST・京大機械翻訳】

Author (25)： Kohler-Forsberg Kristin (1Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark) ,  Kohler-Forsberg Kristin (2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Kohler-Forsberg Kristin (3Department of Psychiatry, Psychiatric Centre Copenhagen, Copenhagen, Denmark) ,  Jorgensen Anders (2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Jorgensen Anders (3Department of Psychiatry, Psychiatric Centre Copenhagen, Copenhagen, Denmark) ,  Dam Vibeke H. (1Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark) ,  Dam Vibeke H. (4Faculty of Health and Medical Sciences, University of Copenhagen, Denmark) ,  Stenbaek Dea Siggaard (1Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark) ,  Fisher Patrick M. (1Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark) ,  Ip Cheng-Teng (1Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark) ,  Ip Cheng-Teng (2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Ip Cheng-Teng (5Department of Clinical Pharmacology, H. Lundbeck A/S, Valby, Denmark) ,  Ganz Melanie (1Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark) ,  Ganz Melanie (6Department of Computer Science, University of Copenhagen, Copenhagen, Denmark) ,  Poulsen Henrik Enghusen (7Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark) ,  Giraldi Annamaria (8Sexological Clinic, Psychiatric Center Copenhagen, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark) ,  Ozenne Brice (1Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark) ,  Ozenne Brice (9Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark) ,  Jorgensen Martin Balslev (2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Jorgensen Martin Balslev (3Department of Psychiatry, Psychiatric Centre Copenhagen, Copenhagen, Denmark) ,  Knudsen Gitte Moos (1Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark) ,  Knudsen Gitte Moos (2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Frokjaer Vibe Gedsoe (1Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark) ,  Frokjaer Vibe Gedsoe (2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) ,  Frokjaer Vibe Gedsoe (3Department of Psychiatry, Psychiatric Centre Copenhagen, Copenhagen, Denmark)
Material： Frontiers in Psychiatry (Web)
Volume： 11  Page： 641  Publication year： 2020 
JST Material Number： U7095A  ISSN： 1664-0640  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Background: Between 30 and 50%...

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Thesaurus term： optimization ,  electroencephalogram ,  antidepressive drug ,  side effect ,  drug therapy ,  *clinical trial ,  *depression(disease) ,  *depression(symptom) ,  pharmacology ,  population(statistics) ,  targeting ,  therapeutic planning ,  PET(tomography) ,  *biomarker ,  nitrogen heterocyclic compound ,  phenolic compound ,  polynuclear aromatic compound ,  primary amine

Author keywords (8)： major depressive disorder ,  biomarker ,  treatment response ,  serotonin 4 receptor ,  positron emission tomography ,  functional magnetic resonance imaging ,  electroencephalogram ,  cognition

JST classification (5)： Clinical application of psychotropic drugs  (GW03110J) ,  Basic research of psychotropic drugs  (GW03100Y) ,  Clinical psychiatry in general  (GR01030T) ,  Drug therapy(=pharmacotherapy)for mental disorders  (GR04020D) ,  Basic psychiatry  (GR01020I)

Substance index (1)： Serotonin

Reference (117)：

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• Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, Murray C, et al. Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010. PloS Med (2013) 10(11):e1001547. doi: doi: 10.1371/journal.pmed.10015473
• Benmansour S, Owens WA, Cecchi M, Morilak DA, Frazer A. Serotonin Clearance In Vivo Is Altered to a Greater Extent by Antidepressant-Induced Downregulation of the Serotonin Transporter than by Acute Blockade of this Transporter. J Neurosci (2002) 22(15):6766-72. doi: doi: 10.1523/jneurosci.22-15-06766.20024
• Smith DF, Jakobsen S. Molecular neurobiology of depression: PET findings on the elusive correlation with symptom severity. Front Psychiatry (2013) 4:8. doi: doi: 10.3389/fpsyt.2013.00008
• Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR*D report. Am J Psychiatry (2006) 163(11):1905-17. doi: doi: 10.1176/ajp.2006.163.11.19056

Terms in the title (14)： セロトニン ,  受容体 ,  PET ,  脳イメージング ,  機能的MRI ,  認知 ,  EEG ,  バイオマーカー ,  うつ病性障害 ,  治療 ,  転帰 ,  予測 ,  ラベル ,  臨床試験プロトコル