Art

J-GLOBAL ID：202002273402573821   Reference number：20A0200342

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group

オレキシン1受容体アンタゴニストYNT-707の必須構造 V 17-アミノ基上の置換基の構造活性相関研究【JST・京大機械翻訳】

Author (14)： Saitoh Tsuyoshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Seki Kazunori (Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan) ,  Nakajima Ryo (Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan) ,  Yamamoto Naoshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Kutsumura Noriki (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Nagumo Yasuyuki (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Irukayama-Tomobe Yoko (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ogawa Yasuhiro (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ishikawa Yukiko (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Yanagisawa Masashi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Yanagisawa Masashi (R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Yanagisawa Masashi (Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States) ,  Nagase Hiroshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Nagase Hiroshi (Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 30  Issue： 3  Page： Null  Publication year： 2020 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The morphinan-type orexin 1 re...

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Thesaurus term： antagonism ,  substituent effect ,  *receptor ,  simplification ,  chemical substance ,  nitrogen heterocyclic compound ,  bridged compound ,  morphinan alkaloid ,  polynuclear aromatic compound
Semi thesaurus term： *アンタゴニスト ,  *置換基 ,  *受容体拮抗薬 ,  *オレキシン , 【Automatic Indexing@JST】

Author keywords (5)： Orexin ,  Nalfurafine ,  YNT-707 ,  Ring removal ,  Substituent effect

JST classification (2)： Structure-activity relationship of drugs  (GV01050B) ,  Synthesis of drugs  (GV01030F)

Substance index (1)： Morphinan

Terms in the title (7)： オレキシン ,  受容体アンタゴニスト ,  YNT-707 ,  アミノ基 ,  置換基 ,  構造活性相関 ,  研究