Art

J-GLOBAL ID：202002273795174323   Reference number：20A0527707

Involvement of monoaminergic targets in the antidepressant- and anxiolytic-like effects of the synthetic alkamide riparin IV: Elucidation of further mechanisms through pharmacological, neurochemistry and computational approaches

合成アルカミドリアriparの抗うつ作用および抗不安様作用におけるモノアミン作動性標的の関与: 薬理学的,神経化学的および計算的アプローチによる更なる機構の解明【JST・京大機械翻訳】

Author (19)： Sartori Danusio Pinheiro (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Oliveira N.F. (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Valentim Jose Tiago (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Silva D.M.A. (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Mallman A.S.V. (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Oliveira I.C.M. (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Chaves R.C. (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Capibaribe V.C. (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Carvalho A.M.R. (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Reboucas M.O. (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Macedo Danielle Silveira (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Chaves Filho Adriano Jose Maia (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Chaves Filho Adriano Jose Maia (LabMol - Laboratory of Molecular Modeling and Drug Design, Faculty of Pharmacy, Federal University of Goias, Goiania, Goiais, Brazil) ,  Fonteles M.M.F. (Department of Pharmacy, Faculty of Pharmacy, Odontology and Nursing, Federal University of Ceara, Fortaleza, Ceara, Brazil) ,  Gutierrez S.J.C. (Laboratory Chemistry of Bioactive Natural and Synthetic Products, Federal University of Piaui, Teresina, Piaui, Brazil) ,  Barbosa-Filho Jose Maria (Pharmaceutical Technology Laboratory, Federal University of Paraiba, Joao Pessoa, Paraiba, Brazil) ,  Mottin Melina (LabMol - Laboratory of Molecular Modeling and Drug Design, Faculty of Pharmacy, Federal University of Goias, Goiania, Goiais, Brazil) ,  Andrade Carolina Horta (LabMol - Laboratory of Molecular Modeling and Drug Design, Faculty of Pharmacy, Federal University of Goias, Goiania, Goiais, Brazil) ,  Sousa F.C.F. (Drug Research and Development Center, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil)
Material： Behavioural Brain Research  (Behav Brain Res)
Volume： 383  Page： Null  Publication year： 2020 
JST Material Number： A1150A  ISSN： 0166-4328  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Despite recent advances, curre...

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Thesaurus term： steric conformation ,  antidepressive drug ,  *depression (symptom) ,  Dopamine D2 Receptor ,  *Pharmacology ,  affinity ,  neural transmission ,  Monoamine Oxidase ,  receptor ,  depression (disease) ,  analgesic action ,  metabolite ,  *antidepressant action ,  GABAA receptor ,  alpha-1 adrenergic receptor

Author keywords (5)： Riparin ,  Depression ,  Antidepressant ,  Monoamines ,  Molecular docking

JST classification (2)： Basic research of psychotropic drugs  (GW03100Y) ,  Basic neurology  (GN01020W)

Terms in the title (6)： 抗うつ作用 ,  モノアミン ,  標的 ,  薬理学 ,  神経化学 ,  計算