Art

J-GLOBAL ID：202002274351218801   Reference number：20A0271463

DJ-1-binding compound B enhances Nrf2 activity through the PI3-kinase-Akt pathway by DJ-1-dependent inactivation of PTEN

DJ-1結合化合物BはPTENのDJ-1依存性不活性化によりPI3-キナーゼ-Akt経路を介してNrf2活性を増強する【JST・京大機械翻訳】

Author (8)： Niki Takeshi (Faculty of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita-ku, Sapporo 060-8589, Japan) ,  Endo Jinro (Faculty of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita-ku, Sapporo 060-8589, Japan) ,  Takahashi-Niki Kazuko (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan) ,  Yasuda Tatsuki (Faculty of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita-ku, Sapporo 060-8589, Japan) ,  Okamoto Asami (Faculty of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita-ku, Sapporo 060-8589, Japan) ,  Saito Yoshiro (Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Ariga Hiroyoshi (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan) ,  Iguchi-Ariga Sanae M.M. (Faculty of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita-ku, Sapporo 060-8589, Japan)
Material： Brain Research  (Brain Res)
Volume： 1729  Page： Null  Publication year： 2020 
JST Material Number： A0705B  ISSN： 0006-8993  CODEN： BRREA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： DJ-1 was identified as an onco...

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Thesaurus term： inactivation ,  oxidative stress ,  oncogene ,  *oxidation ,  phosphatidylinositol 3-kinase ,  Parkinson's disease ,  A549 cell ,  antioxidation ,  cell death
Semi thesaurus term： Keap1蛋白質 ,  *NFE2関連因子2 ,  *Akt/蛋白質キナーゼB ,  *キナーゼ ,  *PTEN ,  *DJ-1蛋白質 , 【Automatic Indexing@JST】

Author keywords (7)： DJ-1-binding compound ,  DJ-1 ,  Parkinson’s disease ,  Oxidative stress ,  Nrf2 ,  PI3K/Akt ,  Keap1

JST classification (4)： Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic neurology  (GN01020W)

Terms in the title (10)： DJ-1 ,  PTEN ,  依存性 ,  不活性化 ,  キナーゼ ,  Akt ,  経路 ,  NRF2 ,  活性 ,  増強