Art

J-GLOBAL ID：202002274510039088   Reference number：20A2371403

Restoration of ligatable “clean” double-strand break ends is the rate-limiting step in the rejoining of ionizing-radiation-induced DNA breakage

ライゲーション可能な”クリーン”二本鎖切断末端の回復は電離放射線誘導DNA切断の再結合における律速段階である【JST・京大機械翻訳】

Author (5)： Sasanuma Hiroyuki (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto, 606-8501, Japan) ,  Yamada Shintaro (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto, 606-8501, Japan) ,  Tsuda Masataka (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto, 606-8501, Japan) ,  Tsuda Masataka (Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Hiroshima, 739-8526, Japan) ,  Takeda Shunichi (Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto, 606-8501, Japan)
Material： DNA Repair
Volume： 93  Page： Null  Publication year： 2020 
JST Material Number： W1339A  ISSN： 1568-7864  Document type： Article
Article type： 文献レビュー  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Radiotherapy kills malignant c...

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Thesaurus term： ionization ,  *recombination (connection) ,  phosphoric acid ,  *DNA ,  nuclease ,  Radiotherapy ,  rate-limiting ,  blocking effect ,  *ionizing radiation ,  directionality ,  monophase ,  *DNA double strand break ,  non-homologous end joining ,  *DNA Cleavage ,  alicyclic compound ,  lactone ,  enzyme inhibitor ,  phenolic compound ,  glycoside (except carbohydrate) ,  olefin compound ,  pyranoside ,  glucoside ,  phenol ether ,  polynuclear aromatic compound

Author keywords (7)： DNA double-strand breaks ,  Non-homologous end joining ,  Etoposide ,  Radiotherapy ,  Ionizing radiation ,  Blocking adducts ,  MRE11

JST classification (1)： Molecular genetics in general  (EC02010J)

Substance index (1)： Etoposide

Terms in the title (9)： ライゲーション ,  クリーン ,  二本鎖切断 ,  回復 ,  電離放射線 ,  誘導 ,  DNA切断 ,  再結合 ,  律速段階