Art

J-GLOBAL ID：202002274867242059   Reference number：20A0967486

Characterisation of isocitrate dehydrogenase 1/isocitrate dehydrogenase 2 gene mutation and the d-2-hydroxyglutarate oncometabolite level in dedifferentiated chondrosarcoma

脱分化軟骨肉腫におけるイソクエン酸デヒドロゲナーゼ1/イソクエン酸デヒドロゲナーゼ2遺伝子突然変異とD-2-ヒドロキシグルタル酸腫瘍代謝産物レベルの特性化【JST・京大機械翻訳】

Author (11)： Mohammad Nissreen (Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada) ,  Wong Derek (Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada) ,  Lum Amy (Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada) ,  Lum Amy (Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, BC, Canada) ,  Lin Jonah (Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada) ,  Ho Julie (Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada) ,  Lee Cheng-Han (Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada) ,  Lee Cheng-Han (Department of Pathology and Laboratory Medicine, BC Cancer, Vancouver, BC, Canada) ,  Yip Stephen (Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada) ,  Yip Stephen (Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, BC, Canada) ,  Yip Stephen (Department of Pathology and Laboratory Medicine, BC Cancer, Vancouver, BC, Canada)
Material： Histopathology
Volume： 76  Issue： 5  Page： 722-730  Publication year： 2020 
JST Material Number： W2598A  ISSN： 0309-0167  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： AIMS: Dedifferentiated chondro...

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Thesaurus term： *isocitrate dehydrogenase ,  *gene ,  *tumor ,  *metabolite ,  *mutation ,  *sarcoma ,  carcinogenesis ,  *dedifferentiation ,  population(statistics) ,  wild type ,  *chondrosarcoma ,  polymerase chain reaction ,  tumorigenesis
Semi thesaurus term： 腫瘍組織 ,  ホルマリン固定パラフィン包埋 , 【Automatic Indexing@JST】

Author keywords (7)： 2-hydroxyglutarate ,  cartilaginous neoplasms ,  dedifferentiated chondrosarcoma ,  IDH mutation ,  IDH1 ,  IDH2 ,  sarcoma

JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Genetic variation  (EC01030Y) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (9)： 分化 ,  軟骨肉腫 ,  イソクエン酸デヒドロゲナーゼ1 ,  イソクエン酸デヒドロゲナーゼ2遺伝子 ,  突然変異 ,  2-ヒドロキシグルタル酸 ,  腫瘍 ,  代謝産物 ,  特性化