Art

J-GLOBAL ID：202002276254906964   Reference number：20A1522395

Can personalized treatment prediction improve the outcomes, compared with the group average approach, in a randomized trial? Developing and validating a multivariable prediction model in a pragmatic megatrial of acute treatment for major depression

個別化治療予測は無作為化試験においてグループ平均アプローチと比較して転帰を改善することができるか?大うつ病に対する急性治療の実際的なメガトライアルにおける多変数予測モデルの開発と検証【JST・京大機械翻訳】

Author (7)： Furukawa Toshi A (Departments of Health Promotion and Human Behavior and of Clinical Epidemiology, Kyoto University Graduate School of Medicine / School of Public Health, Kyoto, Japan) ,  Debray Thomas P A (Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, The Netherlands) ,  Akechi Tatsuo (Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Yamada Mitsuhiko (Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan) ,  Kato Tadashi (Aratama Kokorono Clinic, Nagoya, Japan) ,  Seo Michael (Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland) ,  Efthimiou Orestis (Institute of Social and Preventive Medicine, University of Bern, Switzerland)
Material： Journal of Affective Disorders  (J Affect Disord)
Volume： 274  Page： 690-697  Publication year： 2020 
JST Material Number： A1170A  ISSN： 0165-0327  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： : Clinical trials have traditi...

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Thesaurus term： switching ,  aggregate(material) ,  heart atrium ,  clinical trial ,  *depression(disease) ,  questionnaire ,  *depression(symptom) ,  penalty ,  machine learning ,  randomized controlled trial ,  aggregate ,  *prediction model ,  support vector machine ,  *Individualized Medicine
Semi thesaurus term： *多変量 , 【Automatic Indexing@JST】

Author keywords (4)： Depressive disorder ,  Antidepressive agents ,  Precision medicine ,  Prediction model

JST classification (2)： Drug therapy(=pharmacotherapy)for mental disorders  (GR04020D) ,  Clinical application of psychotropic drugs  (GW03110J)

Terms in the title (12)： 個別化治療 ,  予測 ,  無作為化試験 ,  グループ ,  平均 ,  転帰 ,  大うつ病 ,  治療 ,  多変数 ,  予測モデル ,  開発 ,  検証