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J-GLOBAL ID：202002276311346175   Reference number：20A1025921

Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis

カルシウムチャンネルTRPV6の機能に影響する変異体は早期発症慢性膵炎と関連する【JST・京大機械翻訳】

Author (51)： Masamune Atsushi (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Kotani Hiroshi (Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan) ,  Sorgel Franziska Lena (Else Kroner-Fresenius-Zentrum fuer Ernaehrungsmedizin, Paediatric Nutritional Medicine, Technische Universitaet Muenchen, Freising, Germany) ,  Chen Jian-Min (Inserm, Univ Brest, EFS, UMR 1078, GGB, Brest, France) ,  Hamada Shin (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Sakaguchi Reiko (Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan) ,  Sakaguchi Reiko (Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan) ,  Masson Emmanuelle (Inserm, Univ Brest, EFS, UMR 1078, GGB, Brest, France) ,  Masson Emmanuelle (CHU Brest, Service de Genetique, Brest, France) ,  Nakano Eriko (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Kakuta Yoichi (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Niihori Tetsuya (Department of Medical Genetics, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Funayama Ryo (Division of Cell Proliferation, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Shirota Matsuyuki (Division of Cell Proliferation, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Hirano Tatsuya (Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan) ,  Kawamoto Tetsuya (Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan) ,  Hosokoshi Atsuki (Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan) ,  Kume Kiyoshi (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Unger Lara (Else Kroner-Fresenius-Zentrum fuer Ernaehrungsmedizin, Paediatric Nutritional Medicine, Technische Universitaet Muenchen, Freising, Germany) ,  Ewers Maren (Else Kroner-Fresenius-Zentrum fuer Ernaehrungsmedizin, Paediatric Nutritional Medicine, Technische Universitaet Muenchen, Freising, Germany) ,  Laumen Helmut (Else Kroner-Fresenius-Zentrum fuer Ernaehrungsmedizin, Paediatric Nutritional Medicine, Technische Universitaet Muenchen, Freising, Germany) ,  Bugert Peter (Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-Wuerttemberg-Hessen, Mannheim, Germany) ,  Mori Masayuki X. (Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan) ,  Tsvilovskyy Volodymyr (Pharmakologisches Institut, Universitaet Heidelberg, Heidelberg, Germany) ,  Tsvilovskyy Volodymyr (German Center for Cardiovascular Research, partner site Heidelberg, Germany) ,  Weissgerber Petra (Experimentelle und Klinische Pharmakologie und Toxikologie, Universitaet des Saarlandes, Homburg, Germany) ,  Kriebs Ulrich (Pharmakologisches Institut, Universitaet Heidelberg, Heidelberg, Germany) ,  Kriebs Ulrich (German Center for Cardiovascular Research, partner site Heidelberg, Germany) ,  Fecher-Trost Claudia (Experimentelle und Klinische Pharmakologie und Toxikologie, Universitaet des Saarlandes, Homburg, Germany) ,  Freichel Marc (Pharmakologisches Institut, Universitaet Heidelberg, Heidelberg, Germany) ,  Freichel Marc (German Center for Cardiovascular Research, partner site Heidelberg, Germany) ,  Diakopoulos Kalliope N. (Mildred Scheel Chair of Tumor Metabolism and Comprehensive Cancer Center Munich at the Klinikum rechts der Isar, Technical University of Munich, Munich, Germany) ,  Berninger Alexandra (Mildred Scheel Chair of Tumor Metabolism and Comprehensive Cancer Center Munich at the Klinikum rechts der Isar, Technical University of Munich, Munich, Germany) ,  Lesina Marina (Mildred Scheel Chair of Tumor Metabolism and Comprehensive Cancer Center Munich at the Klinikum rechts der Isar, Technical University of Munich, Munich, Germany) ,  Ishii Kentaro (Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan) ,  Itoi Takao (Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan) ,  Ikeura Tsukasa (Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan) ,  Okazaki Kazuichi (Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan) ,  Kaune Tom (Department of Internal Medicine I, Martin Luther University, Halle (Saale), Germany) ,  Rosendahl Jonas (Department of Internal Medicine I, Martin Luther University, Halle (Saale), Germany) ,  Nagasaki Masao (Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan) ,  Uezono Yasuhito (Cancer Pathophysiology Division, National Cancer Center Research Institute, Tokyo, Japan) ,  Alguel Hana (Mildred Scheel Chair of Tumor Metabolism and Comprehensive Cancer Center Munich at the Klinikum rechts der Isar, Technical University of Munich, Munich, Germany) ,  Nakayama Keiko (Division of Cell Proliferation, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Matsubara Yoichi (National Center for Child Health and Development, Tokyo, Japan) ,  Aoki Yoko (Department of Medical Genetics, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Ferec Claude (Inserm, Univ Brest, EFS, UMR 1078, GGB, Brest, France) ,  Ferec Claude (CHU Brest, Service de Genetique, Brest, France) ,  Mori Yasuo (Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan) ,  Witt Heiko (Else Kroner-Fresenius-Zentrum fuer Ernaehrungsmedizin, Paediatric Nutritional Medicine, Technische Universitaet Muenchen, Freising, Germany) ,  Shimosegawa Tooru (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan)
Material： Gastroenterology
Volume： 158  Issue： 6  Page： 1626-1641.e8  Publication year： 2020 
JST Material Number： H0767A  ISSN： 0016-5085  CODEN： GASTAB  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Changes in pancreatic calcium ...

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Thesaurus term： electric potential ,  enzyme ,  DNA ,  gene ,  receptor ,  nucleotide sequence ,  *pancreatitis ,  population(statistics) ,  caerulein ,  ion channel ,  *calcium channel ,  cystic fibrosis ,  HEK293 cell
Semi thesaurus term： *慢性膵炎 ,  過剰発現 , 【Automatic Indexing@JST】

Author keywords (4)： Genetics ,  Next-generation Sequencing ,  Transient Receptor Potential ,  Whole Exome Sequencing

JST classification (3)： Molecular genetics in general  (EC02010J) ,  Digestive system diseases  (GH03000W) ,  Genetic variation  (EC01030Y)

Terms in the title (6)： カルシウムチャンネル ,  TRPV6 ,  変異体 ,  早期 ,  発症 ,  慢性膵炎