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J-GLOBAL ID：202002278026433903   Reference number：20A2354293

Vitamin D Receptor Deletion Changes Bile Acid Composition in Mice Orally Administered Chenodeoxycholic Acid

ビタミンD受容体の欠失はケノデオキシコール酸を経口投与したマウスの胆汁酸組成を変える

Author (5)： NISHIDA Shigeru (Division of Chemistry, Department of Liberal Arts, Nihon University School of Medicine) ,  ISHIZAWA Michiyasu (Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine) ,  KATO Shigeaki (Graduate School of Science and Engineering, Iryo Sosei University) ,  KATO Shigeaki (Research Institute of Innovative Medicine, Tokiwa Foundation) ,  MAKISHIMA Makoto (Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine)
Material： Journal of Nutritional Science and Vitaminology (Web)
Volume： 66  Issue： 4  Page： 370-374(J-STAGE)  Publication year： 2020 
JST Material Number： U1313A  ISSN： 1881-7742  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： knockout mouse ,...

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Author keywords (5)： vitamin D ,  nuclear receptor ,  lithocholic acid ,  bile acid metabolism ,  bile acid excretion

JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Metabolism and nutrition of lipids  (EJ02034Q)

Substance index (2)： Chenodeoxycholic acid ,  Lithocholic Acid

Reference (26)：

• 1) Hofmann AF. 2009. Bile acids: Trying to understand their chemistry and biology with the hope of helping patients. Hepatology 49: 1403-1418.
• 2) Russell DW. 2009. Fifty years of advances in bile acid synthesis and metabolism. J Lipid Res 50(Suppl): S120-125.
• 3) Ridlon JM, Kang DJ, Hylemon PB. 2006. Bile salt biotransformations by human intestinal bacteria. J Lipid Res 47: 241-259.
• 4) Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM. 2001. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci USA 98: 3375-3380.
• 5) Chiang JY. 2017. Recent advances in understanding bile acid homeostasis. F1000Research 6: 2029.

Terms in the title (7)： ビタミンD受容体 ,  欠失 ,  ケノデオキシコール酸 ,  経口投与 ,  マウス ,  胆汁酸 ,  組成