Art

J-GLOBAL ID：202002278159196053   Reference number：20A1336331

Midline Glioma in Adults: Clinicopathological, Genetic, and Epigenetic Analysis

成人の正中神経膠腫:臨床病理学的,遺伝的およびエピジェネティックな解析

Author (8)： ENOMOTO Toshiyuki (Department of Pathology, Fukuoka University School of Medicine) ,  ENOMOTO Toshiyuki (Department of Neurosurgery, Fukuoka University School of Medicine) ,  AOKI Mikiko (Department of Pathology, Fukuoka University School of Medicine) ,  HAMASAKI Makoto (Department of Pathology, Fukuoka University School of Medicine) ,  ABE Hiroshi (Department of Neurosurgery, Fukuoka University School of Medicine) ,  NONAKA Masani (Department of Neurosurgery, Fukuoka University School of Medicine) ,  INOUE Tooru (Department of Neurosurgery, Fukuoka University School of Medicine) ,  NABESHIMA Kazuki (Department of Pathology, Fukuoka University School of Medicine)
Material： Neurologia Medico-Chirurgica  (神経外科)
Volume： 60  Issue： 3  Page： 136-146(J-STAGE)  Publication year： 2020 
JST Material Number： Z0762A  ISSN： 0470-8105  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： genetic regulation ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A1336331&from=J-GLOBAL&jstjournalNo=Z0762A") }}

Author keywords (5)： diffuse midline glioma ,  adult ,  H3K27M ,  H3K27me3 ,  EZH2

JST classification (1)： Tumors(=neoplasms)of nervous system  (GN04000V)

Reference (29)：

• 1) Louis DN, Ohgaki H, Wiestler OD, Cavenee WK: WHO Classification of Tumours of the Central Nervous System, ed 4. International Agency for Research on Cancer (IARC), Lyon, 2016, pp. 57-59
• 2) Varambally S, Dhanasekaran SM, Zhou M, et al.: The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419: 624-629, 2002
• 3) Helin K, Dhanak D: Chromatin proteins and modifications as drug targets. Nature 502: 480-488, 2013
• 4) Mohammad F, Weissmann S, Leblanc B, et al.: EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas. Nat Med 23: 483-492, 2017
• 5) Purkait S, Sharma V, Jha P, et al.: EZH2 expression in gliomas: Correlation with CDKN2A gene deletion/p16 loss and MIB-1 proliferation index. Neuropathology 35: 421-431, 2015

Terms in the title (6)： 成人 ,  神経膠腫 ,  臨床病理学 ,  遺伝 ,  エピジェネティック ,  解析