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J-GLOBAL ID：202002278778994840   Reference number：20A1562126

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

発癌性変化は調節性T細胞への代謝優位性を与えることにより腫瘍進行を促進する微小環境を創造する【JST・京大機械翻訳】

Author (17)： Kumagai Shogo (Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan) ,  Kumagai Shogo (Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Togashi Yosuke (Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan) ,  Sakai Chika (Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan) ,  Kawazoe Akihito (Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan) ,  Kawazu Masahito (Division of Cellular Signaling, Group for Cancer Development and Progression, National Cancer Center Research Institute, Tokyo, Japan) ,  Ueno Toshihide (Division of Cellular Signaling, Group for Cancer Development and Progression, National Cancer Center Research Institute, Tokyo, Japan) ,  Sato Eiichi (Department of Pathology, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan) ,  Kuwata Takeshi (Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Chiba, Japan) ,  Kinoshita Takahiro (Department of Gastric Surgery, National Cancer Center Hospital East, Chiba, Japan) ,  Yamamoto Masami (Division of Physiological Pathology, Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo, Japan) ,  Nomura Sachiyo (Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Tsukamoto Tetsuya (Department of Pathology, Graduate School of Medicine, Fujita Health University, Aichi, Japan) ,  Mano Hiroyuki (Division of Cellular Signaling, Group for Cancer Development and Progression, National Cancer Center Research Institute, Tokyo, Japan) ,  Shitara Kohei (Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan) ,  Nishikawa Hiroyoshi (Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan) ,  Nishikawa Hiroyoshi (Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan)
Material： Immunity
Volume： 53  Issue： 1  Page： 187-203.e8  Publication year： 2020 
JST Material Number： W1727A  ISSN： 1074-7613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Only a small percentage of pat...

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Thesaurus term： inflammation ,  *tumor ,  tumor cell ,  *carcinogenicity ,  genome ,  immunosuppression ,  free fatty acid ,  targeting ,  stomach tumor ,  phosphatidylinositol 3-kinase ,  *regulatory T cell
Semi thesaurus term： *腫瘍進行 ,  *微小環境 ,  エフェクターT細胞 ,  プログラム細胞死1受容体 , 【Automatic Indexing@JST】

Author keywords (6)： gastric cancer ,  RHOA mutation ,  regulatory T cell ,  fatty acid metabolism ,  non-inflamed tumor ,  PI3K inhibitor

JST classification (1)： Tumor immunity  (ED03040A)

Terms in the title (8)： 発癌性 ,  調節性T細胞 ,  代謝 ,  優位性 ,  腫瘍進行 ,  促進 ,  微小環境 ,  創造