Art

J-GLOBAL ID：202002279010103397   Reference number：20A2735450

Thrombocytosis caused by abnormal molecular chaperone

分子シャペロンの遺伝子異常により引き起こされる血小板増多

Author (1)： ARAKI MARITO (順天堂大学大学院医学研究科輸血・幹細胞制御学)
Material： 日本血栓止血学会誌  (Japanese Journal of Thrombosis and Hemostasis)
Volume： 31  Issue： 5  Page： 491-497(J-STAGE)  Publication year： 2020 
JST Material Number： L2757A  ISSN： 0915-7441  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： CSF ,...
Semi thesaurus term： Thrombopoietin ,...

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Author keywords (10)： essential thrombocythemia ,  myeloproliferative neoplasm ,  calreticulin ,  chaperone ,  MPL ,  essential thrombocythemia ,  myeloproliferative neoplasm ,  calreticulin ,  chaperone ,  MPL

JST classification (1)： Basic hematology  (GK01020N)

Reference (31)：

• 1) Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D’Andrea A, Frohling S, Dohner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG: Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7: 387-397, 2005.
• 2) Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC: A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 352: 1779-1790, 2005.
• 3) James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C, Garcon L, Raslova H, Berger R, Bennaceur-Griscelli A, Villeval JL, Constantinescu SN, Casadevall N, Vainchenker W: A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434: 1144-1148, 2005.
• 4) Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, Vassiliou GS, Bench AJ, Boyd EM, Curtin N, Scott MA, Erber WN, Green AR: Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365: 1054-1061, 2005.
• 5) Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, Cuker A, Wernig G, Moore S, Galinsky I, DeAngelo DJ, Clark JJ, Lee SJ, Golub TR, Wadleigh M, Gilliland DG, Levine RL: MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 3: e270, 2006.

Terms in the title (3)： 分子シャペロン ,  遺伝子異常 ,  血小板増多