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J-GLOBAL ID：202002279100334833   Reference number：20A1175106

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

糖蛋白質CD98HCとの複合体におけるヒトL型アミノ酸輸送体1の低温EM構造【JST・京大機械翻訳】

Author (21)： Lee Yongchan (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan) ,  Lee Yongchan (Department of Structural Biology, Max Planck Institute of Biophysics, Frankfurt, Germany) ,  Wiriyasermkul Pattama (Department of Collaborative Research for Bio-Molecular Dynamics, Nara Medical University, Nara, Japan) ,  Jin Chunhuan (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Quan Lili (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Ohgaki Ryuichi (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Okuda Suguru (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Kusakizako Tsukasa (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan) ,  Nishizawa Tomohiro (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan) ,  Oda Kazumasa (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan) ,  Ishitani Ryuichiro (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan) ,  Ishitani Ryuichiro (Preferred Networks, Inc., Tokyo, Japan) ,  Yokoyama Takeshi (Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Kanagawa, Japan) ,  Nakane Takanori (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan) ,  Nakane Takanori (MRC Laboratory of Molecular Biology, Cambridge, UK) ,  Shirouzu Mikako (Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Kanagawa, Japan) ,  Endou Hitoshi (J-Pharma Co., Ltd, Kanagawa, Japan) ,  Nagamori Shushi (Department of Collaborative Research for Bio-Molecular Dynamics, Nara Medical University, Nara, Japan) ,  Nagamori Shushi (Global Innovation Center, Shiseido Co., Ltd, Kanagawa, Japan) ,  Kanai Yoshikatsu (Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Nureki Osamu (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan)
Material： Nature Structural & Molecular Biology  (Nat Struct Mol Biol)
Volume： 26  Issue： 6  Page： 510-517  Publication year： 2019 
JST Material Number： W0637A  ISSN： 1545-9993  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: The L-type amino aci...

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Thesaurus term： interaction ,  *low temperature ,  *amino acid ,  antitumor action ,  antibody ,  disulfide bond ,  *glycoprotein ,  human(primates) ,  folding(morphology) ,  *complex(substance) ,  heavy chain ,  epitope ,  targeting ,  drug delivery system ,  sterol ,  alicyclic alcohol

JST classification (5)： Cell physiology in general  (EF02010S) ,  Transport of cell membrane  (EF04020R) ,  Biochemistry of antigens,antibodies,complements  (ED04020L) ,  Molecular structure  (EB03020Y) ,  Biological function  (EB03040U)

Substance index (1)： Cholesterol

Terms in the title (6)： 糖蛋白質 ,  複合体 ,  ヒト ,  L型アミノ酸輸送体1 ,  低温 ,  EM