Art

J-GLOBAL ID：202002280362248340   Reference number：20A0583547

UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression

チトクロームP450 3A4活性のUDP-グルクロノシルトランスフェラーゼ(UGT)媒介減衰:抑制のUGTイソ型依存機構【JST・京大機械翻訳】

Author (8)： Miyauchi Yuu (Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan) ,  Miyauchi Yuu (Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan) ,  Tanaka Yoshitaka (Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan) ,  Nagata Kiyoshi (Department of Environmental and Health Science, School of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Yamazoe Yasushi (Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan) ,  Mackenzie Peter I. (Department of Clinical Pharmacology, Flinders Medical Centre and Flinders University, Adelaide, SA, Australia) ,  Yamada Hideyuki (Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan) ,  Ishii Yuji (Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan)
Material： British Journal of Pharmacology  (Br J Pharmacol)
Volume： 177  Issue： 5  Page： 1077-1089  Publication year： 2020 
JST Material Number： B0334A  ISSN： 0007-1188  CODEN： BJPCB  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： BACKGROUND AND PURPOSE: Cytoch...

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Thesaurus term： enzyme ,  rate theory ,  Baculoviridae ,  interaction ,  catalytic activity ,  *cytochrome P450 ,  turnover ,  *UDP glucuronosyltransferase ,  C-terminal side ,  CYP3A ,  Microsomes, Liver ,  Rats, Wistar ,  co-expression ,  controlling element ,  microorganism ,  steroid ,  steroid hormone ,  diene ,  organofluorine compound ,  glucocorticoid ,  enone ,  alicyclic alcohol ,  alicyclic ketone ,  diketone ,  secondary alcohol ,  hydroxy ketone ,  polyol

JST classification (1)： Basic research of psychotropic drugs  (GW03100Y)

Substance index (1)： Dexamethasone

Terms in the title (6)： チトクロームP450 ,  活性 ,  UDP ,  グルクロノシルトランスフェラーゼ ,  減衰 ,  イソ型