Art

J-GLOBAL ID：202002280752849391   Reference number：20A2808684

Epicutaneous allergen administration without antigen delivery device induces local T cell response and alleviates food allergic enteropathy

抗原送達デバイスなしの皮膚上アレルゲン投与は局所T細胞応答を誘発して食物アレルギー性腸疾患を緩和する

Author (13)： Morinaga Mamiko (Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ,  Morinaga Mamiko (Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ,  Nakajima-Adachi Haruyo (Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ,  Nakajima-Adachi Haruyo (Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ,  Hiraide Erika (Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ,  Hiraide Erika (Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ,  Kitamura Noriko (Department of Genome Medicine, Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science) ,  Kaminuma Osamu (Department of Genome Medicine, Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science) ,  Kaminuma Osamu (Department of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University) ,  Hiroi Takachika (Department of Genome Medicine, Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science) ,  Ohashi-Doi Katsuyo (Research Laboratories, Torii Pharmaceutical Co., Ltd.) ,  Hachimura Satoshi (Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ,  Hachimura Satoshi (Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo)
Material： Allergology International  (Allergol Int)
Volume： 69  Issue： 4  Page： 622-625(J-STAGE)  Publication year： 2020 
JST Material Number： L6446A  ISSN： 1323-8930  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： disease model mouse ,...

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JST classification (2)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Immunological reaction in general  (ED03010T)

Reference (17)：

• 1. Senti G, von Moos S, Tay F, Graf N, Johansen P, Kündig TM. Determinants of efficacy and safety in epicutaneous allergen immunotherapy: summary of three clinical trials. Allergy 2015;70:707-10.
• 2. Mondoulet L, Dioszeghy V, Vanoirbeek JA, Nemery B, Dupont C, Benhamou PH. Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts. Int Arch Allergy Immunol 2011;154:299-309.
• 3. Mondoulet L, Dioszeghy V, Larcher T, Ligouis M, Dhelft V, Puteaux E, et al. Epicutaneous immunotherapy (EPIT) blocks the allergic esophago-gastro-enteropathy induced by sustained oral exposure to peanuts in sensitized mice. PLoS One 2012;7:e31967.
• 4. Dioszeghy V, Mondoulet L, Dhelft V, Ligouis M, Puteaux E, Dupont C, et al. The regulatory T cells induction by epicutaneous immunotherapy is sustained and mediates long-term protection from eosinophilic disorders in peanut-sensitized mice. Clin Exp Allergy 2014;44:867-81.
• 5. Dioszeghy V, Mondoulet L, Puteaux E, Dhelft V, Ligouis M, Plaquet C, et al. Differences in phenotype, homing properties and suppressive activities of regulatory T cells induced by epicutaneous, oral or sublingual immunotherapy in mice sensitized to peanut. Cell Mol Immunol 2017;14:770-82.

Terms in the title (10)： 抗原 ,  送達 ,  皮膚 ,  アレルゲン ,  投与 ,  T細胞応答 ,  誘発 ,  食物アレルギー ,  腸疾患 ,  緩和