Art

J-GLOBAL ID：202002281197486039   Reference number：20A0277773

In situ monitoring of the crystalline state of active pharmaceutical ingredients during high-shear wet granulation using a low-frequency Raman probe

低周波Ramanプローブを用いた高剪断湿式造粒中の活性薬剤成分の結晶状態のその場モニタリング【JST・京大機械翻訳】

Author (5)： Nomura Kazuya (Department of Molecular Pharmaceutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan) ,  Titapiwatanakun Varin (Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok 10330, Thailand) ,  Hisada Hiroshi (Department of Molecular Pharmaceutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan) ,  Koide Tatsuo (Division of Drugs, National Institute of Health Sciences, Tonomachi 3-25-26, Kawasaki-ku, Kawasaki City, Kanagawa 210-9501, Japan) ,  Fukami Toshiro (Department of Molecular Pharmaceutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan)
Material： European Journal of Pharmaceutics and Biopharmaceutics  (Eur J Pharm Biopharm)
Volume： 147  Page： 1-9  Publication year： 2020 
JST Material Number： B0129B  ISSN： 0939-6411  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Optimization of manufacturing ...

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Thesaurus term： wetting(humidity) ,  optimization ,  quality control ,  production process ,  crystal morphology ,  hydrate ,  probe ,  hydroxypropyl cellulose ,  crystal face ,  *shear(mechanics) ,  *crystal ,  filler(pharmaceuticals) ,  *LF
Semi thesaurus term： 共結晶 ,  *湿式造粒 , 【Automatic Indexing@JST】

Author keywords (4)： Low-frequency Raman probe ,  High-shear wet granulation ,  Crystal form conversion ,  Wet granulator

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Solid preparations  (GY02030V)

Terms in the title (8)： 低周波 ,  プローブ ,  剪断 ,  湿式造粒 ,  活性 ,  薬剤 ,  結晶状態 ,  モニタリング