Art

J-GLOBAL ID：202002281262266401   Reference number：20A0430149

Edgeworthia gardneri (Wall.) Meisn. Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3β/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes

ヒトHepG2肝細胞においてEdgeworthia Gardneri(Wall)MeisnはIrs1/GSK3β/FOXO1シグナル伝達経路を調節することによりパルミチン酸誘導インスリン抵抗性を改善する【JST・京大機械翻訳】

Author (11)： Zhang Yi (1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China) ,  Yan Li Shan (1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China) ,  Ding Yu (1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China) ,  Cheng Brian Chi Yan (2College of Professional and Continuing Education, Hong Kong Polytechnic University, Hong Kong, China) ,  Cheng Brian Chi Yan (3Chinese Medicine Department of Quality Healthcare Medical Services , Hong Kong, China) ,  Luo Gan (1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China) ,  Kong Jing (1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China) ,  Liu Tong Hua (1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China) ,  Liu Tong Hua (4Tibetan Medicine Department of Tibetan Traditional Medical College, Lhasa, China) ,  Zhang Shuo Feng (1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China) ,  Zhang Shuo Feng (4Tibetan Medicine Department of Tibetan Traditional Medical College, Lhasa, China)
Material： Frontiers in Pharmacology (Web)
Volume： 10  Page： 1666  Publication year： 2019 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The flower of Edgeworthia gard...

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Thesaurus term： *human(primates) ,  up-regulation ,  glycogen ,  *insulin resistance ,  *hepatocyte ,  Western blotting ,  pharmacology ,  down-regulation ,  triglyceride ,  GLUT4 ,  survival ratio ,  *HepG2 cell ,  type 2 diabetes mellitus ,  phosphorylation ,  translocation(genetics)

Author keywords (5)： Edgeworthia gardneri ,  insulin resistance ,  palmitate ,  IRS1/GSK3β/FoxO1 signaling pathway ,  HepG2 cells

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Reference (62)：

• Ashcroft F. M., Rorsman P. (2012). Diabetes mellitus and the beta cell: the last ten years. Cell 148 (6), 1160-1171. doi: doi: 10.1016/j.cell.2012.02.010
• Assad M., Jackson N. (2019). “"Biocompatibility evaluation of orthopedic biomaterials and medical devices: a review of safety and efficacy models,"” in Encyclopedia of Biomedical Engineering, vol. 281-309 . Ed. Narayan R. (Oxford: Elsevier). doi: 10.1016/j.cell.2012.02.010
• Bankhead P. (2014). Analyzing fluorescence microscopy images with ImageJ. ImageJ 1, 195. doi: doi: 10.1109/NER.2015.7146654
• Bi L., Chiang J. Y., Ding W. X., Dunn W., Roberts B., Li T. (2013). Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice. J. Lipid Res. 54 (10), 2754-2762. doi: doi: 10.1194/jlr.M039347
• Boden G., Lebed B., Schatz M., Homko C., Lemieux S. (2001). Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50 (7), 1612-1617. doi: doi: 10.2337/diabetes.50.7.1612

Terms in the title (11)： ヒト ,  HepG2 ,  肝細胞 ,  IRS1 ,  GSK3β ,  FoxO1 ,  シグナル伝達経路 ,  調節 ,  パルミチン酸 ,  誘導 ,  インスリン抵抗性